RT Journal Article
T1 Modelling vascular morphogenesis: current views on blood vessels development
A1 Herrero, Miguel A.
A1 Köhn Luque, Álvaro
A1 Pérez-Pomares, José M.
AB In this work we present a comprehensive account of our current knowledge on vascular morphogenesis, both from a biological and a mathematical point of view. To this end, we first describe the basic steps in the known mechanisms of blood vessel morphogenesis, whose structure, function and unfolding properties are examined. We then provide a wide, although by no means exhaustive, account of mathematical models which are used to describe and discuss particular aspects of the overall biological process considered. We finally summarize the approaches presented, and suggest possible directions for future research. Details about some of the major signalling molecules involved are included in a first Appendix at the end of the paper. A second Appendix provides a brief overview of design principles for vascular nets, a subject that has deserved considerable attention over the years.
PB World Scientific
SN 0218-2025
YR 2009
FD 2009-08
LK https://hdl.handle.net/20.500.14352/42308
UL https://hdl.handle.net/20.500.14352/42308
LA eng
NO Banco Santander Central Hispano
NO Universidad Complutense de Madrid
NO Ministerio de Ciencia e Innovacion, Spain
NO European Community's Sixth Framework Programme contract ("HeartRepair")
NO ISCIII cooperative and thematic research networks RECAVA and TERCEL
DS Docta Complutense
RD 7 abr 2025