RT Journal Article
T1 Lack of a Synergistic Effect on Cardiometabolic and Redox Markers in a Dietary Supplementation with Anthocyanins and Xanthophylls in Postmenopausal Women
A1 Estévez Santiago, Rocío
A1 Silván, José Manuel
A1 Can Cauich, Cesar Abraham
A1 Veses, Ana Maria
A1 Álvarez Acero, Inma
A1 Martínez Bartolome, Miguel Ángel
A1 San Román, Ricardo
A1 Cámara Hurtado, María De La Montaña
A1 Olmedilla Alonso, Begoña
A1 Pascual Teresa, Sonia De
AB Fruits and vegetables are pivotal for a healthy diet due partly to their content in bioactive compounds. It is for this reason that we conducted a parallel study to unravel the possible effect on cardiometabolic parameters of the ingestion of anthocyanins, xanthophylls, or both groups of bioactives together in postmenopausal women. Seventy-two postmenopausal women were randomized into an 8-month parallel study: a group consuming 60 mg/day anthocyanins (Group A), a group consuming 6 mg lutein and 2 mg zeaxanthin per day (Group X), and a third group consuming a combination of anthocyanins and xanthophylls in the same amounts (Group A+X). Non-targeted metabolomic analysis was done in plasma samples at baseline and after the 8-month intervention by HPLC-QTOF-MS. Inflammatory, antioxidant, and cardiometabolic parameters were measured at the beginning of the study and after 4 and 8-months intervention. Compared with baseline values, none of the 8-month treatments significantly (p < 0.05) changed systolic or diastolic blood pressure (BP), plasma C-reactive protein, interleukin 6, vascular cell adhesion molecule-1, intercellular adhesion molecule-1, monocyte chemoattractant protein-1 or matrix metalloproteinases 2 and 9. Only plasma glucose levels were significantly decreased by treatment A+X after 8 months, and the plasma metabolomic profile was clearly affected by all three dietary supplementations after 8 months. In parallel, there was an increase, also for the three groups, in the plasma ferric reducing antioxidant power value that did not show any synergistic effect between the two groups of bioactives. Postmenopausal women could benefit from an increase in anthocyanins and xanthophylls intake, through the consumption of fruits and vegetables rich in these two types of compounds. Accordingly, plasma glucose and, above all, the reducing power in plasma, could be improved.
PB MDPI
SN 2072-6643
YR 2019
FD 2019-07-05
LK https://hdl.handle.net/20.500.14352/12666
UL https://hdl.handle.net/20.500.14352/12666
LA eng
NO Estévez Santiago, R., Silván, J. M., Can Cauich, C. A. et al. «Lack of a Synergistic Effect on Cardiometabolic and Redox Markers in a Dietary Supplementation with Anthocyanins and Xanthophylls in Postmenopausal Women». Nutrients, vol. 11, n.o 7, julio de 2019, p. 1533. DOI.org (Crossref), https://doi.org/10.3390/nu11071533.
NO Ministerio de Ciencia, Innovación y Universidades (España)
DS Docta Complutense
RD 6 abr 2025