RT Journal Article
T1 Lipid Metabolic Alterations in the ALS–FTD Spectrum of Disorders
A1 Godoy Corchuelo, Juan Miguel
A1 Fernández Beltrán, Luis Carlos
A1 Ali, Zeinab
A1 Gil Moreno, María José
A1 Lopez Carbonero, Juan
A1 Guerrero Sola, Antonio
A1 Larrad Sainz, Angélica
A1 Matías-Guiu Guía, Jorge
A1 Matias Guiu, Jordi A.
A1 Cunningham, Thomas J.
A1 Corrochano, Silvia
AB There is an increasing interest in the study of the relation between alterations in systemic lipid metabolism and neurodegenerative disorders, in particular in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). In ALS these alterations are well described and evident not only with the progression of the disease but also years before diagnosis. Still, there are some discrepancies in findings relating to the causal nature of lipid metabolic alterations, partly due to the great clinical heterogeneity in ALS. ALS presentation is within a disorder spectrum with Frontotemporal Dementia (FTD), and many patients present mixed forms of ALS and FTD, thus increasing the variability. Lipid metabolic and other systemic metabolic alterations have not been well studied in FTD, or in ALS–FTD mixed forms, as has been in pure ALS. With the recent development in lipidomics and the integration with other -omics platforms, there is now emerging data that not only facilitates the identification of biomarkers but also enables understanding of the underlying pathological mechanisms. Here, we reviewed the recent literature to compile lipid metabolic alterations in ALS, FTD, and intermediate mixed forms, with a view to appraising key commonalities or differences within the spectrum.
PB MDPI
SN 2227-9059
YR 2022
FD 2022-05-10
LK https://hdl.handle.net/20.500.14352/72146
UL https://hdl.handle.net/20.500.14352/72146
LA eng
NO Godoy Corchuelo, J. M., Fernández Beltrán, L. C., Ali, Z. et al. «Lipid Metabolic Alterations in the ALS–FTD Spectrum of Disorders». Biomedicines, vol. 10, n.o 5, mayo de 2022, p. 1105. DOI.org (Crossref), https://doi.org/10.3390/biomedicines10051105.
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Comunidad de Madrid
DS Docta Complutense
RD 10 abr 2025