RT Journal Article
T1 New insights into the sensitization to nonspecific lipid transfer proteins from pollen and food: New role of allergen Ole e 7
A1 Oeo‐Santos, Carmen
A1 Navas, Ana
A1 Benedé Pérez, Sara
A1 Ruíz‐León, Berta
A1 Díaz‐Perales, Araceli
A1 Vogel, Lothar
A1 Moreno‐Aguilar, Carmen
A1 Jurado, Aurora
A1 Villalba Díaz, María Teresa
A1 Barderas Manchado, Rodrigo
AB Background: Ole e 7 is a nonspecific lipid transfer protein (nsLTP) from olive pollen, one of the main allergenic pollens worldwide. This allergenic nsLTP is responsible for severe symptoms in regions with high olive pollen exposure, where many Ole e 7‐sensitized patients exhibit a co‐sensitization to the peach nsLTP, Pru p 3. However, there is no evidence of cross‐reactivity, which explains this observed co‐sensitization. Therefore, the purpose of this study was to explore the relationship between Ole e 7 and Pru p 3.Methods: A total of 48 patients sensitized to Ole e 7 and/or Pru p 3 were included in the study. Specific IgE serum levels were measured by ImmunoCAP 250 and ELISA. Inhibition assays were performed to determine the existence of cross‐reactivity be‐ tween both nsLTPs. Allergic response was analyzed ex vivo (basophil activation test) and in vitro (RBL‐2H3 mast cell model).Results: Common IgG and IgE epitopes were identified between both allergens. IgE‐ binding inhibition was detected in Ole e 7–monosensitized patients using rPru p 3 as inhibitor, reaching inhibition values of 25 and 100%. Ex vivo and in vitro assays revealed a response against rPru p 3 in four (31%) Ole e 7–monosensitized patients.Conclusions: Our results suggest that Ole e 7 could play a new role as primary sen‐ sitizer in regions with high olive pollen exposure, leading to the peach nsLTP sensi‐ tization. This co‐sensitization process would occur because of the cross‐reactivity between Ole e 7 and Pru p 3 observed in some allergic patients
PB Wiley
SN 0105-4538
YR 2019
FD 2019
LK https://hdl.handle.net/20.500.14352/93542
UL https://hdl.handle.net/20.500.14352/93542
LA eng
NO Oeo‐Santos, Carmen, et al. «New Insights into the Sensitization to Nonspecific Lipid Transfer Proteins from Pollen and Food: New Role of Allergen Ole e 7». Allergy, vol. 75, n.o 4, abril de 2020, pp. 798-807. https://doi.org/10.1111/all.14086.
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Instituto de Salud Carlos III
NO Junta de Andalucía
DS Docta Complutense
RD 8 abr 2025