RT Journal Article
T1 Effects of Postbiotic Administration on Canine Health: A Systematic Review and Meta-Analysis.
A1 Bonel Ayuso, Diego Paul
A1 Pineda Pampliega, Javier
A1 Martinez Alesón García, Paloma
A1 Fernández-Muela Garrote, Montserrat
A1 Fuente Vázquez, Jesús De La
A1 García Fernández, Paloma María
A1 Isabel Redondo, Beatriz
AB Postbiotics-defined in 2021 by the International Scientific Association of Probiotics and Prebiotics (ISAPP) as preparations of inactivated microorganisms and/or their components that confer health benefits to the host-are a promising tool in veterinary medicine. This systematic review and meta-analysis evaluated their types, mechanisms of action, and physiological effects in dogs. A literature search was conducted in PubMed, Scopus, and Web of Science up to 10 October 2024. Eligible studies included peer-reviewed trials in dogs or mechanistic studies on postbiotics; studies in other species or without peer review were excluded. Risk of bias was assessed, and random-effects meta-analyses were performed when appropriate. Of 157 records, 69 met the inclusion criteria, including 13 in vivo studies in dogs. Meta-analyses of selected outcomes showed no statistically significant differences between postbiotic and control groups. Evidence is limited by small sample sizes, strain heterogeneity, and varied study designs. Despite nonsignificant results, existing evidence from other species suggests that postbiotics improve the gut microbiota composition, modulate immune and inflammatory responses, reduce oxidative stress, and aid in the treatment of chronic conditions such as atopic dermatitis. Taken together with their potential role as an alternative to antimicrobial use, these findings highlight the need for further research in canine health to support the use of postbiotics in the treatment of common canine diseases, either as a standalone therapy or in combination with existing therapeutic options.
PB MDPI
YR 2025
FD 2025
LK https://hdl.handle.net/20.500.14352/123404
UL https://hdl.handle.net/20.500.14352/123404
LA eng
NO Bonel-Ayuso, D. P., Pineda-Pampliega, J., Martinez-Alesón García, P., Fernandez-Muela, M., de la Fuente, J., Garcia Fernandez, P. M., & Isabel Redondo, B. (2025). Effects of Postbiotic Administration on Canine Health: A Systematic Review and Meta-Analysis. Microorganisms, 13(7), 1572. https://doi.org/10.3390/microorganisms13071572
NO Author Contributions: Conceptualization, B.I.R. and P.M.G.F.; methodology, P.M.-A.G.; software, J.P.-P. and D.P.B.-A.; validation, J.d.l.F., B.I.R. and P.M.G.F.; formal analysis, D.P.B.-A.; investigation, D.P.B.-A.; resources, D.P.B.-A.; data curation, M.F.-M.; writing—original draft preparation, D.P.B.-A.; writing—review and editing, B.I.R., J.P.-P., P.M.G.F. and J.d.l.F.; visualization, M.F.-M.; supervision, B.I.R., P.M.G.F. and J.d.l.F.; project administration, B.I.R.; funding acquisition, B.I.R. All authors have read and agreed to the published version of the manuscript
NO Centro para el Desarrollo Tecnológico y la Innovación
DS Docta Complutense
RD 27 mar 2026