%0 Journal Article
%A Dominguez Centeno, Isabel
%A Jurado Barba, Rosa
%A Sion, Ana Mª Alexandra
%A Martínez Maldonado, Andrés
%A Castillo Parra, Gabriela
%A López Muñoz, Francisco
%A Rubio Valladolid, Gabriel
%A Martínez Gras, María Isabel
%T P3 component as a potential endophenotype for control inhibition in offspring of alcoholics
%D 2018
%U https://hdl.handle.net/20.500.14352/133801
%X Aims: To assess inhibitory processes and the ongoing event-related potential (ERP) activity of offspring of alcoholics (OA) during a Go/No-Go task, with the purpose of characterizing possible psychophysiological endophenotypes for alcohol-dependent vulnerability.Methods: ERP measurements were obtained by electroencephalogram (EEG) recordings of 65 participants divided into two groups: one group of 30 subjects with positive family history of alcoholism and a control group of 35 subjects with negative family history of alcoholism. They performed a Go/No-Go task, where each individual was required to classify visual stimuli by colour (Go) and inhibit their response to a No-Go signal.Results: OA have higher P3 amplitudes during the Go condition in all of the regions analysed and higher No-Go P3 amplitudes than control subjects in the frontal region. Unlike controls, OA have no differences between the P3 amplitudes across conditions.Conclusions: The absence of differences between the P3 Go and No-Go observed in the OA group can be interpreted as a possible alteration related with inhibition, in a way that they may need to recruit similar resources for inhibitory and classificational processes for both conditions. Therefore, the P3 component may be considered as a useful endophenotype and a vulnerability marker to develop addictive behaviour.
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