RT Journal Article
T1 P3 component as a potential endophenotype for control inhibition in offspring of alcoholics
A1 Dominguez Centeno, Isabel
A1 Jurado Barba, Rosa
A1 Sion, Ana Mª Alexandra
A1 Martínez Maldonado, Andrés
A1 Castillo Parra, Gabriela
A1 López Muñoz, Francisco
A1 Rubio Valladolid, Gabriel
A1 Martínez Gras, María Isabel
AB Aims: To assess inhibitory processes and the ongoing event-related potential (ERP) activity of offspring of alcoholics (OA) during a Go/No-Go task, with the purpose of characterizing possible psychophysiological endophenotypes for alcohol-dependent vulnerability.Methods: ERP measurements were obtained by electroencephalogram (EEG) recordings of 65 participants divided into two groups: one group of 30 subjects with positive family history of alcoholism and a control group of 35 subjects with negative family history of alcoholism. They performed a Go/No-Go task, where each individual was required to classify visual stimuli by colour (Go) and inhibit their response to a No-Go signal.Results: OA have higher P3 amplitudes during the Go condition in all of the regions analysed and higher No-Go P3 amplitudes than control subjects in the frontal region. Unlike controls, OA have no differences between the P3 amplitudes across conditions.Conclusions: The absence of differences between the P3 Go and No-Go observed in the OA group can be interpreted as a possible alteration related with inhibition, in a way that they may need to recruit similar resources for inhibitory and classificational processes for both conditions. Therefore, the P3 component may be considered as a useful endophenotype and a vulnerability marker to develop addictive behaviour.
PB Oxford University Press
YR 2018
FD 2018-11
LK https://hdl.handle.net/20.500.14352/133801
UL https://hdl.handle.net/20.500.14352/133801
LA eng
NO I Domínguez-Centeno, R Jurado-Barba, A Sion, A Martinez-Maldonado, G Castillo-Parra, F López-Muñoz, G Rubio, I Martinez-Gras. P3 Component as a Potential Endophenotype for Control Inhibition in Offspring of Alcoholics, Alcohol and Alcoholism, Volume 53, Issue 6, November 2018, Pages 699–706, https://doi.org/10.1093/alcalc/agy051
NO Ministerio de Sanidad, Servicios Sociales e Igualdad (España)
DS Docta Complutense
RD 21 mar 2026