RT Journal Article
T1 Precision nutrition impact on metabolic health and quality of life in aging population after a 3-month intervention: A randomized intervention
A1 Galarregui, Cristina
A1 Navas Carretero, Santiago
A1 Zulet, María Ángeles
A1 González Navarro, Carlos J.
A1 Martínez, J. Alfredo
A1 De Cuevillas, Begoña
A1 Marcos Pasero, Helena
A1 Aguilar Aguilar, Elena
A1 Reglero, Guillermo
A1 Ramirez de Molina, Ana
A1 Chausa, Paloma
A1 Iniesta, Jose M.
A1 Hernando, M. Elena
A1 Gómez, Enrique J.
A1 García Rudolph, Alejandro
A1 García Molina, Alberto
A1 Loria Kohen, Viviana Constanza
A1 Abete, Itziar
A2 Elsevier, 
AB Objectives: Innovative precision dietary procedures are required to promote healthy aging. This study aimed to evaluate the effects of a personalised strategy based on the inclusion of individualised foods and digital tools on overall health status and quality of life within a follow-up of 3 months in older adults with overweight or obesity.Methods: 127 men and women aged between 50 and 80 years with overweight/obesity participated in the study-between January 2020 and September 2020 at the Center for Nutrition Research-University of Navarra and IMDEA-ALIMENTACIÓN-and were randomly assigned to a usual-care group (standard recommendations) or precision group (precision nutrition strategy based on the inclusion of individualised foods and a mobile application). Anthropometry, body fat percentage, biochemical parameters, diet, and quality of life (SF-36 Health Survey) were assessed at baseline and after 3 months.Results: Both strategies were found to improve overall metabolic health; however, the precision approach demonstrated significantly better outcomes. The precision strategy reduced body weight at 3 months (-4.3 kg; p < 0.001) with significant improvements in body fat percentage, blood pressure and general metabolic health (glycated haemoglobin; alanine aminotransferase; aspartate aminotransferase; hepatic steatosis index) in comparison with the standard recommendations. The precision approach significantly enhanced the quality of life (SF-36) of individuals, with additional improvements in emotional well-being (p = 0.024) and vitality (p = 0.008). Adherence to the Mediterranean diet was significantly associated with a higher quality of life and vitality.Conclusion: These results support the benefit of precision nutrition approaches for promoting healthy aging and emotional well-being, enhancing the quality of life in aging populations, during the COVID-19 pandemic.
PB Elsevier
SN 1279-7707
YR 2024
FD 2024-06-07
LK https://hdl.handle.net/20.500.14352/104959
UL https://hdl.handle.net/20.500.14352/104959
LA eng
NO Galarregui C, Navas-Carretero S, Zulet MA, González-Navarro CJ, Martínez JA, de Cuevillas B, Marcos-Pasero H, Aguilar-Aguilar E, Reglero G, Ramirez de Molina A, Chausa P, Iniesta JM, Hernando ME, Gómez EJ, Garcia-Rudolph A, García-Molina A, Loria-Kohen V, Abete I. Precision nutrition impact on metabolic health and quality of life in aging population after a 3-month intervention: A randomized intervention. J Nutr Health Aging. 2024 Jun 11;28(7):100289. doi: 10.1016/j.jnha.2024.100289. Epub ahead of print. PMID: 38865737.
NO Ministerio de Economía, Comercio y Empresa (España)
DS Docta Complutense
RD 16 abr 2025