RT Journal Article
T1 Neuronal excitation/inhibition imbalance: core element of a translational perspective on Alzheimer pathophysiology
A1 Maestú Unturbe, Fernando
A1 de Haan, Willem
A1 Busche, Marc Aurel
A1 DeFelipe, Javier
AB Our incomplete understanding of the link between Alzheimer’s Disease pathology and symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies have begun to connect the dots between protein alterations and deposition, brain network dysfunction and cognitive deficits. Disturbance of neuronal activity, and in particular an imbalance in underlying excitation/inhibition (E/I), appears early in AD, and can be regarded as forming a central link between structural brain pathology and cognitive dysfunction. While there are emerging (non-)pharmacological options to influence this imbalance, the complexity of human brain dynamics has hindered identification of an optimal approach. We suggest that focusing on the integration of neurophysiological aspects of AD at the micro-, meso- and macroscale, with the support of computational network modeling, can unite fundamental and clinical knowledge, provide a general framework, and suggest rational therapeutic targets.
PB Elsevier
SN 1568-1637
YR 2021
FD 2021-05-21
LK https://hdl.handle.net/20.500.14352/8609
UL https://hdl.handle.net/20.500.14352/8609
LA eng
NO CRUE-CSIC (Acuerdos Transformativos 2021)
NO Ministerio de Ciencia e Innovación (MICINN)
NO BrightFocus Foundation
NO Centro de Investigación en Red sobre Enfermedades Neurodegenerativas (CIBERNED)
DS Docta Complutense
RD 22 abr 2025