RT Journal Article
T1 Sex-specific regulation of inhibition and network activity by local aromatase in the mouse hippocampus
A1 Hernández Vivanco, Alicia
A1 Cano Adamuz, Nuria
A1 González Alonso, Alba
A1 Sánchez-Aguilera López, Alberto
A1 Rodríguez Fernández, Alberto
A1 Azcoitia Elías, Íñigo
A1 Menéndez de la Prida, Liset
A1 Méndez, Pablo
AB Cognitive function relies on a balanced interplay between excitatory and inhibitory neurons (INs), but the impact of estradiol on IN function is not fully understood. Here, we characterize the regulation of hippocampal INs by aromatase, the enzyme responsible for estradiol synthesis, using a combination of molecular, genetic, functional and behavioral tools. The results show that CA1 parvalbumin-expressing INs (PV-INs) contribute to brain estradiol synthesis. Brain aromatase regulates synaptic inhibition through a mechanism that involves modification of perineuronal nets enwrapping PV-INs. In the female brain, aromatase modulates PV-INs activity, the dynamics of network oscillations and hippocampal-dependent memory. Aromatase regulation of PV-INs and inhibitory synapses is determined by the gonads and independent of sex chromosomes. These results suggest PV-INs are mediators of estrogenic regulation of behaviorally-relevant activity.
PB Nature Research
YR 2022
FD 2022-07
LK https://hdl.handle.net/20.500.14352/95092
UL https://hdl.handle.net/20.500.14352/95092
LA eng
NO Hernández-Vivanco A, Cano-Adamuz N, Sánchez-Aguilera A, González-Alonso A, Rodríguez-Fernández A, Azcoitia Í, de la Prida LM, Méndez P. Sex-specific regulation of inhibition and network activity by local aromatase in the mouse hippocampus. Nat Commun. 2022 Jul 7;13(1):3913. doi: 10.1038/s41467-022-31635-3
DS Docta Complutense
RD 19 abr 2025