RT Journal Article
T1 Contact Lenses as Drug Delivery System for Glaucoma: A Review
A1 Peral Cerdá, Assumpta
A1 Martínez Águila, Alejandro
A1 Pastrana, Cristina
A1 Huete Toral, Fernando
A1 Carpena Torres, Carlos
A1 Carracedo Rodríguez, Juan Gonzalo
AB Glaucoma is an optical neuropathy associated to a progressive degeneration of retinal ganglion cells with visual field loss and is the main cause of irreversible blindness in the world. The treatment has the aim to reduce intraocular pressure. The first therapy option is to instill drugs on the ocular surface. The main limitation of this is the reduced time of the drug staying on the cornea. This means that high doses are required to ensure its therapeutic effect. A drug-loaded contact lens can diffuse into the post lens tear film in a constant and prolonged flow, resulting in an increased retention of the drug on the surface of the cornea for up to 30 min and thus providing a higher drug bioavailability, increasing the therapeutic efficacy, reducing the amount of administered drug, and thereby provoking fewer adverse events. Several different systems of drug delivery have been studied in recent decades; ranging from more simple methods of impregnating the lenses, such as soaking, to more complex ones, such as molecular imprinting have been proposed. Moreover, different drugs, from those already commercially available to new substances such as melatonin have been studied to improve the glaucoma treatment efficacy. This review describes the role of contact lenses as an innovative drug delivery system to treat glaucoma.
PB MDPI
SN 2076-3417
YR 2020
FD 2020-07-27
LK https://hdl.handle.net/20.500.14352/6474
UL https://hdl.handle.net/20.500.14352/6474
LA eng
NO Received: 30 June 2020; Accepted: 21 July 2020; Published: 27 July 2020
NO Ministerio de Economía y Competitividad (MINECO)
NO Redes temáticas de investigación cooperativa en salud (RETICS)
DS Docta Complutense
RD 7 may 2024