RT Journal Article
T1 New Trends in Aging Drug Discovery
A1 Benhamú Salama, Bellinda
A1 Martín-Fontecha Corrales, María Del Mar
A1 Vázquez Villa, María Del Henar
A1 López Rodríguez, María Luz
A1 Ortega Gutiérrez, Silvia
AB Aging is considered the main risk factor for many chronic diseases that frequently appear at advanced ages. However, the inevitability of this process is being questioned by recent research that suggests that senescent cells have specific features that differentiate them from younger cells and that removal of these cells ameliorates senescent phenotype and associated diseases. This opens the door to the design of tailored therapeutic interventions aimed at reducing and delaying the impact of senescence in life, that is, extending healthspan and treating aging as another chronic disease. Although these ideas are still far from reaching the bedside, it is conceivable that they will revolutionize the way we understand aging in the next decades. In this review, we analyze the main and well-validated cellular pathways and targets related to senescence as well as their implication in aging-associated diseases. In addition, the most relevant small molecules with senotherapeutic potential, with a special emphasis on their mechanism of action, ongoing clinical trials, and potential limitations, are discussed. Finally, a brief overview of alternative strategies that go beyond the small molecule field, together with our perspectives for the future of the field, is provided.
PB MDPI
SN 2227-9059
YR 2022
FD 2022-08-15
LK https://hdl.handle.net/20.500.14352/73306
UL https://hdl.handle.net/20.500.14352/73306
LA eng
NO Ministerio de Ciencia e Innovación de España
DS Docta Complutense
RD 8 abr 2025