RT Journal Article
T1 Electrospraying as a Technique for the Controlled Synthesis of Biocompatible PLGA@Ag2S and PLGA@Ag2S@SPION Nanocarriers with Drug Release Capability
A1 Alvear Jiménez, Alexis
A1 Zabala Gutiérrez, Irene
A1 Shen, Yingli
A1 Villaverde Cantizano, Gonzalo
A1 Lozano Chamizo, Laura
A1 Guardia, Pablo
A1 Tinoco Rivas, Miguel
A1 García Pinel, Beatriz
A1 Prados, José
A1 Melguizo, Consolación
A1 López Romero, Manuel
A1 Jaque, Daniel
A1 Filice, Marco
A1 Contreras Cáceres, Rafael
AB Ag2S nanoparticles are near-infrared (NIR) probes providing emission in a specific spectral range (~1200 nm), and superparamagnetic iron oxide nanoparticles (SPION) are colloidal systems able to respond to an external magnetic field. A disadvantage of Ag2S NPs is the attenuated luminescent properties are reduced in aqueous media and human fluids. Concerning SPION, the main drawback is the generation of undesirable clusters that reduce particle stability. Here, we fabricate biocompatible hybrid nanosystems combining Ag2S NPs and SPION by the electrospraying technique for drug delivery purposes. These nanostructures are composed of poly(lactic-co-glycolic acid) (PLGA) as the polymeric matrix in connection with both Ag2S NPs and SPIONs. Initially, we fabricate a hybrid colloidal nanosystem composed of Ag2S NPs in connection with PLGA (PLGA@Ag2S) by three different routes, showing good photoluminescent (PL) properties with relatively high average decay times. Then, we incorporate SPIONs, obtaining a PLGA polymeric matrix containing both Ag2S NPs and SPION (PLGA@Ag2S@SPION). Interestingly, in this hybrid system, the location of Ag2S NPs and SPIONs depends on the synthesis route performed during electrospraying. After a detailed characterization, we demonstrate the encapsulation and release capabilities, obtaining the kinetic release using a model chemotherapeutic drug (maslinic acid). Finally, we perform in vitro cytotoxicity assays using drug-loaded hybrid systems against several tumor cell lines.
YR 2022
FD 2022
LK https://hdl.handle.net/20.500.14352/94750
UL https://hdl.handle.net/20.500.14352/94750
LA eng
NO Alvear-Jiménez, A.; Zabala Gutierrez, I.; Shen, Y.; Villaverde, G.; Lozano-Chamizo, L.; Guardia, P.; Tinoco, M.; Garcia-Pinel, B.; Prados, J.; Melguizo, C.; et al. Electrospraying as a Technique for the Controlled Synthesis of Biocompatible PLGA@Ag2S and PLGA@Ag2S@SPION Nanocarriers with Drug Release Capability. Pharmaceutics 2022, 14, 214. https://doi.org/10.3390/pharmaceutics14010214
NO Comunidad de Madrid
NO European Commission
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Instituto de Salud Carlos III
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 12 abr 2025