%0 Generic
%A Gutiérrez Ramos, Irene
%T Interacción del cannabidiol con rafts lipídicos
%D 2025
%U https://hdl.handle.net/20.500.14352/124828
%X Cannabidiol (CBD), a phytocannabinoid with a wide pharmacological spectrum, could interfere in processes at the cell membrane because of its lipid nature. The hypothesis of  this study is that CBD interacts with lipid rafts, membrane domains enriched in  sphingolipids and cholesterol essentials for cell signaling. The analysis of the  physicochemical properties of membranes and interfacial monolayers made of a lipid raft  model composed of palmitoyloleoylphosphatidylcholine, sphingomyelin and cholesterol  (1:1:1 molar ratio) revealed that (1) CBD binds to lipid rafts, segregating sphingomyelin from  cholesterol and reducing lipid packing, and (2) CBD aggregation limits its interaction with membranes. These results suggest a new mechanism of action by which this drug could alter cell signaling.
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