%0 Journal Article
%A Hernandez-Rocamora, V.M.
%A Maestro García-Donas, María Beatriz
%A de Waal, B.
%A Morales, M.
%A Garcia, P.
%A Meijer, E. W.
%A Sanz, J.M.
%T Multivalent Choline Dendrimers as Potent Inhibitors of Pneumococcal Cell-Wall Hydrolysis
%D 2009
%@ 1433-7851
%U https://hdl.handle.net/20.500.14352/93420
%X Dendritic cell-wall mimics: Choline-binding proteins from Streptococcus pneumoniae recognize distinctive multivalent choline architectures on the bacterial cell wall. Choline-functionalized dendrimers are potent inhibitors of these essential enzymes, with a 103–104-fold higher affinity than free choline, resulting in inhibition of autolysis and cell separation in bacterial cultures at low micromolar concentrations
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