RT Journal Article
T1 Multivalent Choline Dendrimers as Potent Inhibitors of Pneumococcal Cell-Wall Hydrolysis
A1 Hernandez-Rocamora, V.M.
A1 Maestro García-Donas, María Beatriz
A1 de Waal, B.
A1 Morales, M.
A1 Garcia, P.
A1 Meijer, E. W.
A1 Sanz, J.M.
AB Dendritic cell-wall mimics: Choline-binding proteins from Streptococcus pneumoniae recognize distinctive multivalent choline architectures on the bacterial cell wall. Choline-functionalized dendrimers are potent inhibitors of these essential enzymes, with a 103–104-fold higher affinity than free choline, resulting in inhibition of autolysis and cell separation in bacterial cultures at low micromolar concentrations
PB Wiley
SN 1433-7851
YR 2009
FD 2009-01-13
LK https://hdl.handle.net/20.500.14352/93420
UL https://hdl.handle.net/20.500.14352/93420
LA eng
NO Escuela Valenciana de Estudios para la Salud
NO Fundación Salvat Inquifarma
NO Ministerio de Educación y Ciencia (MEC)
NO Instituto de Salud Carlos III
NO Comunidad de Madrid
NO Netherlands Organisation for Scientific Research
DS Docta Complutense
RD 25 abr 2025