RT Journal Article
T1 Low expression of CD39 and CD73 genes in centenarians compared with octogenarians
A1 Crooke Álvarez, Almudena
A1 Martínez Henández, Juan
A1 Martínez López, Joaquín
A1 Cruz Jentoft, Alfonso
A1 Huete Toral, Fernando
A1 Pintor Just, Jesús Jerónimo
AB Ageing involves a progressive decline of the body’s regulatory systems including immune system. Adenosine regulates immune function by interaction with its receptors, mainly adenosine A2A receptor, present on the surface of immune cells. Furthermore, cellular response to this nucleoside is highly dependent on its extracellular concentration that is regulated by ecto-enzymes such as CD39 and CD73. Therefore, the aim of this study was to investigate the effect of age on adenosine A2A receptor, CD39 and CD73 gene expression. Changes in mRNA were measured by quantitative PCR from peripheral blood of young, middle-aged and older adults as well as centenarians. Centenarians showed a prominent decrease of CD39 and CD73 mRNA in comparison with older adults. Regarding to adenosine A2A receptor, we detected two subgroups of centenarians with high and low level of transcript. Additionally, adenosine A2A receptor mRNA level of centenarians, did not correlate with their cognitive impairment. In summary, our pilot study suggests that unlike of adenosine A2A receptor, the level of CD39 as well as CD73 mRNA could be a hallmark of successful human ageing.
PB BioMed Central LTD
SN 1742-4933
YR 2017
FD 2017-05-19
LK https://hdl.handle.net/20.500.14352/17822
UL https://hdl.handle.net/20.500.14352/17822
LA eng
NO Crooke Álvarez, A., Martínez Henández, J., Martínez López, J. et al. «Low expression of CD39 and CD73 genes in centenarians compared with octogenarians». Immunity & Ageing, vol. 14, n.o 1, mayo de 2017, p. 11. BioMed Central, https://doi.org/10.1186/s12979-017-0094-3.
NO Ministerio de Economía, Comercio y Empresa (España)
NO Ministerio de Sanidad (España)
DS Docta Complutense
RD 25 ago 2024