RT Journal Article
T1 Is saffron able to prevent the dysregulation of retinal cytokines induced by ocular hypertension in mice?
A1 Fernández Albarral, José
A1 Martínez López, Miguel Ángel
A1 Marco López, Eva María
A1 Hoz Montañana, María Rosa De
A1 Martín Sánchez, Beatriz
A1 San Felipe Riba, Diego
A1 García Martín, Elena Salobrar
A1 López Cuenca, Inés
A1 Pinazo Durán, María Dolores
A1 Salazar Corral, Juan José
A1 Ramírez Sebastián, José Manuel
A1 López-Gallardo, Meritxell
A1 Ramírez Sebastián, Ana Isabel
AB Cytokine- and chemokine-mediated signalling is involved in the neuroinflammatory process that leads to retinal ganglion cell (RGC) damage in glaucoma. Substances with anti-inflammatory properties could decrease these cytokines and chemokines and thus prevent RGC death. The authors of this study analysed the anti-inflammatory effect of a hydrophilic saffron extract standardized to 3% crocin content, focusing on the regulation of cytokine and chemokine production, in a mouse model of unilateral laser-induced ocular hypertension (OHT). We demonstrated that following saffron treatment, most of the concentration of proinflammatory cytokines (IL-1β, IFN-γ, TNF-α, and IL-17), anti-inflammatory cytokines (IL-4 and IL-10), Brain-derived Neurotrophic Factor (BDNF), Vascular Endothelial Growth Factor (VEGF), and fractalkine were unaffected in response to laser-induced OHT in both the OHT eye and its contralateral eye. Only IL-6 levels were significantly increased in the OHT eye one day after laser induction compared with the control group. These results differed from those observed in animals subjected to unilateral OHT and not treated with saffron, where changes in cytokine levels occurred in both eyes. Therefore, saffron extract regulates the production of proinflammatory cytokines, VEGF, and fractalkine induced by increasing intraocular pressure (IOP), protecting the retina from inflammation. These results indicate that saffron could be beneficial in glaucoma by helping to reduce the inflammatory process
PB MDPI
SN 2077-0383
YR 2021
FD 2021
LK https://hdl.handle.net/20.500.14352/4517
UL https://hdl.handle.net/20.500.14352/4517
LA eng
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Instituto de Salud Carlos III
NO Universidad Complutense de Madrid
NO Banco de Santander
DS Docta Complutense
RD 20 abr 2025