RT Journal Article
T1 Lichen depsides and tridepsides: progress in pharmacological approaches
A1 Ureña Vacas, Isabel María
A1 González Burgos, Elena María
A1 Dulare Devi, Pradeep Divakar
A1 Gómez-Serranillos Cuadrado, María Pilar
AB Depsides and tridepsides are secondary metabolites found in lichens. In the last 10 years, there has been a growing interest in the pharmacological activity of these compounds. This review aims to discuss the research findings related to the biological effects and mechanisms of action of lichen depsides and tridepsides. The most studied compound is atranorin, followed by gyrophoric acid, diffractaic acid, and lecanoric acid. Antioxidant, cytotoxic, and antimicrobial activities are among the most investigated activities, mainly in in vitro studies, with occasional in silico and in vivo studies. Clinical trials have not been conducted using depsides and tridepsides. Therefore, future research should focus on conducting more in vivo work and clinical trials, as well as on evaluating the other activities. Moreover, despite the significant increase in research work on the pharmacology of depsides and tridepsides, there are many of these compounds which have yet to be investigated (e.g., hiascic acid, lassalic acid, ovoic acid, crustinic acid, and hypothamnolic acid).
PB MDPI
YR 2023
FD 2023-01-14
LK https://hdl.handle.net/20.500.14352/104429
UL https://hdl.handle.net/20.500.14352/104429
LA eng
NO Ureña-Vacas I, González-Burgos E, Divakar PK, Gómez-Serranillos MP. Lichen Depsides and Tridepsides: Progress in Pharmacological Approaches. JoF. 2023;9:116.
NO 2023 Descuento MDPI
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Universidad Complutense de Madrid
NO Grupo Santander
DS Docta Complutense
RD 25 abr 2025