RT Journal Article
T1 Short-term Effect of Scleral Lens on the Dry Eye Biomarkers in Keratoconus
A1 Carracedo Rodríguez, Juan Gonzalo
A1 Serramito Blanco, María
A1 Martín Gil, Alba
A1 Wang, Zicheng
A1 Carballo Álvarez, Jesús
A1 Pintor, Jesús
AB Purpose: To evaluate the most important signs of dry eye, such as osmolarity, inflammation, and diadenosine tetraphosphate (Ap4A) concentration before and after wearing scleral lenses for 8 h in keratoconus patients.Methods: A pilot, experimental, short-term study involved 26 keratoconus patients (average age, 36.95 ± 8.95 years). They voluntarily enrolled in the study at the Optometry Clinic of the Faculty of Optics and Optometry in the University Complutense of Madrid. They were divided into two groups: patients with intrastromal corneal ring, the ICRS group, and patients without ICRS, the keratoconus (KC) group. Ocular Surface Disease Index questionnaire, the Schirmer test without anesthesia, tear break-up time, matrix metalloproteinase 9 (MMP-9) concentration, osmolarity, and Ap4A concentration were evaluated before and after wearing a scleral lens for 8 h.Results: The patients wore the scleral lenses from 6 to 9 h, with a mean of 7.59 ± 0.73 h. The mean scleral lens sag for all patients was 4310 ± 166.31 μm, ranging from 4200 μm to 4800 μm. No significant changes in the Schirmer test and tear break-up time were found for either group. Ocular Surface Disease Index scores were statistically lower after wearing scleral lenses for both groups (p < 0.05). A significantly lower osmolarity and a significant rise of MMP-9 concentration after wearing scleral lenses were found in both groups (p < 0.05). Diadenosine tetraphosphate concentration was lower after wearing the scleral lens in the KC group (p < 0.05) but no significant difference was found for the ICRS group (p > 0.05).Conclusions: Short-term scleral lens wearing improves the symptomatology and some signs of dry eye, such as osmolarity and Ap4A concentration. The increase of MMP-9 concentration could be caused by tear film stagnation and use of preserved saline.
PB Lippincott Williams & Wilkins
SN 1040-5488
YR 2016
FD 2016-02
LK https://hdl.handle.net/20.500.14352/23256
UL https://hdl.handle.net/20.500.14352/23256
LA eng
NO Received June 14, 2015; accepted September 22, 2015.
NO Ministerio de Ciencia e Innovación (MICINN)
NO RETICS (Redes Temáticas de Investigación Cooperativa en Salud)
DS Docta Complutense
RD 6 abr 2025