RT Journal Article T1 Differences in Sex and the Incidence and In-Hospital Mortality among People Admitted for Infective Endocarditis in Spain, 2016–2020 A1 Miguel Yanes, José María De A1 Jiménez García, Rodrigo A1 Miguel Díez, Javier De A1 Hernández Barrera, Valentín A1 Carabantes Alarcón, David A1 Zamorano León, José Javier A1 Noriega, Concepción A1 López De Andrés, Ana Isabel AB (1) Background: A description of the trends and outcomes during hospitalization for infective endocarditis (IE) according to sex. (2) Methods: Using Spanish national hospital discharge data (2016–2020), we built Poisson regression models to compare the age-adjusted time trends for the incidence rate. We used propensity score matching (PSM) to compare the clinical characteristics and the in-hospital mortality (IHM) between men and women hospitalized with IE. (3) Results: We identified 10,459 hospitalizations for IE (33.26% women). The incidence of IE remained stable during this five-year period. The age-adjusted incidence of IE was two-fold higher among men vs. women (IRR = 2.08; 95%CI 2.0–2.17). Before PSM, women with IE were significantly older than men (70.25 vs. 66.24 years; p < 0.001) and had lower comorbidity according to the Charlson comorbidity index (mean 1.38 vs. 1.43; p = 0.019). After PSM, the IHM among women admitted for IE remained >3 points higher than that among men (19.52% vs. 15.98%; p < 0.001). (4) Conclusions: The incidence of IE was two-fold higher among men than among women. IHM was significantly higher among women after accounting for the potential confounders. PB MDPI SN 2077-0383 YR 2022 FD 2022-11-20 LK https://hdl.handle.net/20.500.14352/72301 UL https://hdl.handle.net/20.500.14352/72301 LA eng NO Miguel Yanes, J. M., Jiménez García, R., Miguel Díez, J. et al. «Differences in Sex and the Incidence and In-Hospital Mortality among People Admitted for Infective Endocarditis in Spain, 2016–2020». Journal of Clinical Medicine, vol. 11, n.o 22, noviembre de 2022, p. 6847. DOI.org (Crossref), https://doi.org/10.3390/jcm11226847. NO Comunidad de Madrid NO Universidad Complutense de Madrid NO Universidad Complutense de Madrid. Grupo de Investigación en Epidemiología de las Enfermedades Crónicas de Alta Prevalencia en España (970970). DS Docta Complutense RD 10 abr 2025