RT Journal Article
T1 Vectorization of ultrasound-responsive nanoparticles in placental mesenchymal stem cells for cancer therapy
A1 Paris, J.L.
A1 Torre, Paz de la
A1 Cabañas Criado, María Victoria
A1 Manzano García, Miguel
A1 Grau, Montserrat
A1 Flores, Ana I.
A1 Vallet Regí, María Dulce Nombre
AB A new platform constituted by engineered responsive nanoparticles transported by human mesenchymal stem cells is here presented as a proof of concept. Ultrasound-responsive mesoporous silica nanoparticles are coated with polyethylenimine to favor their effective uptake by decidua-derived mesenchymal stem cells. The responsive-release ability of the designed nanoparticles is confirmed, both in vial and in vivo. In addition, this capability is maintained inside the cells used as carriers. The migration capacity of the nanoparticle-cell platform towards mammary tumors is assessed in vitro. The efficacy of this platform for anticancer therapy is shown against mammary tumor cells by inducing the release of doxorubicin only when the cell vehicles are exposed to ultrasound.
PB Royal Society of Chemistry
SN 2040-3364
YR 2017
FD 2017-05-07
LK https://hdl.handle.net/20.500.14352/17828
UL https://hdl.handle.net/20.500.14352/17828
LA eng
NO Unión Europea. FP7
NO Ministerio de Economía y Competitividad (MINECO)
NO Comunidad de Madrid
NO Neurosciences and Aging Foundation
NO Francisco Soria Melguizo Foundation
NO Octopharma
NO Parkinson Madrid
DS Docta Complutense
RD 11 abr 2025