RT Journal Article
T1 Oral immunogenicity of the plant derived spike protein from swine-transmissible gastroenteritis coronavirus
A1 Gómez, Nestor
A1 Wigdorovitz, Andres
A1 Castañón, Sonia
A1 Gil Dones, Félix
A1 Ordá, Ricardo
A1 Borca, Manuel
A1 Escribano, José
AB Transgenic plants represent an inexpensive alternative to classical fermentation systems for production of recombinant subunit vaccines. Transgenic potato plants were created that express the N-terminal domain of the glycoprotein S (N-gS) from Transmissible gastroenteritis coronavirus (TGEV), containing the major antigenic sites of the protein. Extracts from potato tubers expressing N-gS were inoculated intraperitoneally to mice, and the vaccinated mice developed serum IgG specific for TGEV. Furthermore, when potato tubers expressing N-gS were fed directly to mice, they developed serum antibodies specific for gS protein, demonstrating the oral immunogenicity of the plant derived spike protein from TGEV.
PB Springer
SN 0304-8608
YR 2000
FD 2000
LK https://hdl.handle.net/20.500.14352/94970
UL https://hdl.handle.net/20.500.14352/94970
LA eng
NO Gómez, N., Wigdorovitz, A., Castañón, S. et al. Oral immunogenicity of the plant derived spike protein from swine-transmissible gastroenteritis coronavirus. Arch. Virol. 145, 1725–1732 (2000). https://doi.org/10.1007/s007050070087
DS Docta Complutense
RD 17 abr 2025