RT Journal Article
T1 Medical Imaging for the Tracking of Micromotors
A1 Vilela García, Diana
A1 Cossío, Unai
A1 Parmar, Jemish
A1 Martínez-Villacorta, Angel
A1 Gómez-Vallejo, Vanessa
A1 Llop, Jordi
A1 Sánchez, Samuel
AB Micro/nanomotors are useful tools for several biomedical applications, including targeted drug delivery and minimally invasive microsurgeries. However, major challenges such as in vivo imaging need to be addressed before they can be safely applied on a living body. Here, we show that positron emission tomography (PET), a molecular imaging technique widely used in medical imaging, can also be used to track a large population of tubular Au/PEDOT/Pt micromotors. Chemisorption of an iodine isotope onto the micromotor’s Au surface rendered them detectable by PET, and we could track their movements in a tubular phantom over time frames of up to 15 min. In a second set of experiments, micromotors and the bubbles released during self-propulsion were optically tracked by video imaging and bright-field microscopy. The results from direct optical tracking agreed with those from PET tracking, demonstrating that PET is a suitable technique for the imaging of large populations of active micromotors in opaque environments, thus opening opportunities for the use of this mature imaging technology for the in vivo localization of artificial swimmers.
PB American Chemical Society (ACS)
SN 1936-0851
YR 2018
FD 2018
LK https://hdl.handle.net/20.500.14352/96710
UL https://hdl.handle.net/20.500.14352/96710
LA eng
NO Diana Vilela, Unai Cossío, Jemish Parmar, Angel M. Martínez-Villacorta, Vanessa Gómez-Vallejo, Jordi Llop, and Samuel SánchezACS Nano 2018 12 (2), 1220-1227DOI: 10.1021/acsnano.7b07220
NO European Commission
NO Ministerio de Economía y Competitividad (España)
NO Alexander von Humboldt Foundation
NO Euskal Herriko Komunitate Autonomoaren
DS Docta Complutense
RD 11 abr 2025