RT Journal Article
T1 Hard-to-heal wound healing: superiority of hydrogel EHO-85 (containing Olea europaea leaf extract) vs. a standard hydrogel. A randomized controlled trial
A1 Verdú Soriano, Jose
A1 Casado Díaz, Antonio
A1 Cristino Espinar, Marisol de
A1 Luna Morales, Silvia
A1 Dios Guerra, Caridad
A1 Moreno Moreno, Paloma
A1 Dorado, Gabriel
A1 Quesada Gomez, Jose Manuel
A1 Rodríguez Mañas, Leocadio
A1 Lázaro Martínez, José Luis
AB Chronic wounds, especially those that are hard-to-heal, constitute a serious public-health problem. Although progress has been made in the development of wound dressings for healing, there is little high-quality evidence of their efficacy, with no evidence of superiority in the use of one hydrogel over another. To evaluate the superiority of a hydrogel (EHO-85), containing Olea europaea leaf extract (OELE), over a standard hydrogel (SH), the promotion and/or improvement of healing of difficult-to-heal wounds was compared in a prospective, parallel-group multicenter, randomized, observer-blinded, controlled trial (“MACAON”). Non-hospitalized patients with pressure, venous or diabetic foot-ulcers difficult-to-heal were recruited and treated with standard care, and EHO-85 (n = 35) or VariHesive (n = 34) as SH. Wound-area reduction (WAR; percentage) and healing rate (HR; mm2/day) were measured. EHO-85 showed a statistically significant superior effect over VariHesive. At the end of the follow-up period, the relative WAR decreased by 51.6% vs. 18.9% (p < 0.001), with a HR mean of 10.5   5.7 vs. 1.0   7.5 mm2/day (p = 0.036). EHO-85 superiority is probably based on its optimal ability to balance the ulcer bed, by modulating pH and oxidative stress. That complements the wetting and barrier functions, characteristics of conventional hydrogels. These results support the use of EHO-85 dressing, for treatment of hard-to-heal ulcers. Trial Registration AEMPS:PS/CR623/17/CE.
PB MDPI
YR 2023
FD 2023-12
LK https://hdl.handle.net/20.500.14352/103579
UL https://hdl.handle.net/20.500.14352/103579
LA eng
NO Verdú-Soriano, J.; Casado-Díaz, A.; de Cristino-Espinar, M.; Luna-Morales, S.; Dios-Guerra, C.; Moreno-Moreno, P.; Dorado, G.; Quesada-Gómez, J.M.; Rodríguez-Mañas, L.; Lázaro-Martínez, J.L. Hard-to-Heal Wound Healing: Superiority of Hydrogel EHO-85 (Containing Olea europaea Leaf Extract) vs. a Standard Hydrogel. A Randomized Controlled Trial. Gels 2023, 9, 962. https://doi.org/10.3390/gels9120962
NO 2023 Descuento MDPI
NO Quesper R&D
NO Ministerio de Economía y Competitividad (España)
NO Junta de Andalucía
DS Docta Complutense
RD 26 dic 2025