RT Journal Article
T1 Soluble defense collagens: sweeping up immune threats
A1 Casals Carro, María Cristina
A1 García-Fojeda, Belén
A1 Minutti, Carlos M.
AB Soluble defense collagens form a group of secreted proteins that are primarily involved in host defense. All defense collagens contain a globular recognition domain contiguous to a collagen-like triple helical domain. They are oligomeric proteins, assembled in multiples of three subunits due to their collagen domains. Members of this group include collectins such as surfactant protein A and D (SP-A, SP-D), and mannan-binding lectin; C1q, the first component of the complement system; adiponectin; and ficolins. All are secreted to tissue cavities or serum. Soluble defense collagens are specialized to respond to infection, triggering the initiation of the complement cascade and/or enhancing phagocytosis of pathogens by macrophages. However, once inflammation is established, C1q, collectins, ficolins, or adiponectin can influence macrophage responses, thereby contributing to resolve the inflammation. In addition, some members of this group of proteins (SP-A, C1q, and adiponectin) modulate tissue-repair functions of macrophages. This review will focus on the molecular mechanisms by which these proteins efficiently defend against immune threats and contribute to tissue repair.
PB Elsevier
SN 0161-5890, ESSN: 1872-9142
YR 2019
FD 2019-08
LK https://hdl.handle.net/20.500.14352/13474
UL https://hdl.handle.net/20.500.14352/13474
LA eng
NO Casals C, García-Fojeda B, Minutti CM. Soluble defense collagens: Sweeping up immune threats. Molecular Immunology 2019; 112: 291–304. [DOI: 10.1016/j.molimm.2019.06.007]
NO Ministerio de Ciencia e Innovación (España)
NO Instituto de Salud Carlos III (España)
DS Docta Complutense
RD 26 abr 2026