RT Journal Article
T1 Probability and predictors of remission from life-time prescription drug use disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions
A1 Blanco, Carlos
A1 Secades-Villa, Roberto
A1 García-Rodríguez, Olaya
A1 Labrador Méndez, Marta Isabel
A1 Wang, Shuai
A1 Schwartz, Robert
AB While prescription drug use disorders (PDUD) has become an important and growing public health problem, little is known about their course. This study aims to estimate cumulative probability of remission from sedatives, tranquilizers, opioids and stimulants, and to identify predictors of remission across substances. Analyses were done for the sub-sample of individuals with lifetime history of abuse or dependence on sedatives (n = 402), tranquilizers (n = 372), opioids (n = 521), and stimulants (n = 765) at Wave 1 of the National Epidemiological Survey on Alcohol and Related Conditions (NESARC). Cumulative probability estimates and hazard ratios for remission from PDUD were obtained for the general population. Lifetime cumulative probability estimates of remission were above 96% for all substances assessed. Half of the cases of PDUD remitted between 4 and 5 years after onset. Remission from PDUD was greater for younger individuals. Males exhibited lower hazards of remission for stimulants use disorder. A diagnosis of personality disorders decreased probability of remission for sedatives and stimulants. Only abuse or dependence on some prescription drugs decreased the probability of remission from other PDUD, whereas other drug disorders did not predict remission. A significant proportion of individuals with PDUD achieve remission at some point in their life-time. Predictors of remission were found to be mostly substance-specific rather than common across substances. The lower rates of remission among some subgroups of the population highlight the need to strengthen preventive and intervention efforts among vulnerable population subgroups.
PB Elsevier
SN 0022-3956
YR 2013
FD 2013
LK https://hdl.handle.net/20.500.14352/91929
UL https://hdl.handle.net/20.500.14352/91929
LA eng
NO Blanco, C., Secades-Villa, R., Garcia-Rodriguez, O., Labrador-Mendez, M., Wang, S., & Schwartz, R. P. (2013). Probability and predictors of remission from life-time prescription drug use disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Journal of psychiatric research, 47(1), 42-49.
NO National Institute on Alcohol Abuse and Alcoholism (USA)
NO National Institute on Drug Abuse (USA)
DS Docta Complutense
RD 17 abr 2025