RT Journal Article
T1 Impaired Immune Response in Old Mice Suffering from Obesity and Premature Immunosenescence in Adulthood
A1 Hunsche, Caroline
A1 Hernández, Oskarina
A1 Fuente del Rey, Mónica de la
AB Obesity and aging share an impaired immune system and oxidative and inflammatory stress. Therefore, the hypothesis of obesity as a possible model of premature immunosenescence has been proposed. In this study, we investigated whether adult obese mice, as a consequence of being fed with a fat-rich diet during their adolescence, showed premature immunosenescence and if this was aggravated with aging. Peritoneal cell suspensions were obtained when ICR/CD1 obese female mice were adults (28 weeks) and old (72 weeks), and several functions and antioxidant defenses were evaluated. The results showed that the chemotaxis of both macrophages and lymphocytes, phagocytosis of macrophages, activity of natural killer cells, proliferative response of lymphocytes, interleukin-1β, tumor necrosis factor-alpha, interleukin-6, interleukin-2, and interleukin-10 released in leukocyte cultures, as well as antioxidant and oxidant capacity were significantly impaired in adult obese mice with respect to adult nonobese mice, with values similar to those in chronologically old mice. When these obese animals grew older, although having been fed with a standard diet, they showed a higher deterioration of their immune functions in comparison with the old control group. In conclusion, these results demonstrate that a high fat intake during adolescence can produce an obesity state in adult age associated with a premature immunosenescence, which is aggravated through aging.
PB The Gerontological Society of America
SN 1079-5006
YR 2016
FD 2016
LK https://hdl.handle.net/20.500.14352/23316
UL https://hdl.handle.net/20.500.14352/23316
LA eng
NO Ministerio de Ciencia e Innovación (MICINN)
NO Universidad Complutense de Madrid
NO RETICEF, Instituto de Salud Carlos III (ISCIII-FEDER)
DS Docta Complutense
RD 11 may 2025