RT Journal Article
T1 Radiation-induced cranial tumors: clinical series and literature review
A1 Garbizu, Jose Manuel
A1 Mateo Sierra, Olga
A1 Pérez Calvo, José María
A1 Iza, Begoña
A1 Ruiz Juretschke, Fernando
AB Radiation induced tumors are well-known but rare complications of radiotherapy. Meningiomas are the most common radiation-induced (RI) cranial tumors, followed by gliomas and sarcomas, while other tumors as haemangioblastomas remain extremely exceptional. We present 7 patients with RI brain tumors diagnosed and treated at our institution between 1990 and 2006. Retrospective review of their clinical charts is supplied. All patients were irradiated during childhood as a treatment for another disease, and fulfilled the criteria of RI neoplasia. Four patients developed meningiomas and three developed other tumors (one glioblastoma, one softtissue sarcoma and one hemangioblastoma). In all cases a complete surgical removal was achieved. Preoperative assessment based on MRI supplied the correct diagnosis in six patients. The most important risks factors described in the literature for developing RI tumors are the age at which radiotherapy was administered and the dose of radiation applied. Differential diagnosis of RI tumors includes any tumor appearing after radiotheraphy, especially recurrences of the primary disease, as RI neoplasias are a rare complication. Even in cases with complete surgical resection, prognosis of this clinical entity is basically related to the histology of the RI tumor.
PB Elsevier
SN 1130-1473
YR 2008
FD 2008-01
LK https://hdl.handle.net/20.500.14352/129066
UL https://hdl.handle.net/20.500.14352/129066
LA spa
NO Garbizu JM, Mateo-Sierra O, Pérez-Calvo JM, Iza B, Ruiz-Juretschke F. Tumores craneales radioinducidos: serie clínica y revisión de la literatura [Radiation-induced cranial tumors: clinical series and literature review]. Neurocirugia (Astur). 2008 Aug;19(4):332-7.
DS Docta Complutense
RD 19 mar 2026