RT Journal Article
T1 Triangulating the associations of different types of childhood adversity and first-episode psychosis with cortical thickness across brain regions
A1 Fares Otero, Natalia E.
A1 Melero Carrasco, Helena
A1 García Bueno, Borja
A1 Rapado Castro, Marta
A1 Martínez Gras, María Isabel
A1 Rodríguez Jiménez, Roberto
A1 Díaz Marsa, Marina Francisca
A1 Arango López, Celso
A1 Martínez Díaz-Caneja, María Covadonga
A1 Radua, Joaquim
AB BackgroundBoth childhood adversity (CA) and first-episode psychosis (FEP) have been linked to alterations in cortical thickness (CT). The interactive effects between different types of CAs and FEP on CT remain understudied.MethodsOne-hundred sixteen individuals with FEP (mean age = 23.8 ± 6.9 years, 34% females, 80.2% non-affective FEP) and 98 healthy controls (HCs) (mean age = 24.4 ± 6.2 years, 43% females) reported the presence/absence of CA <17 years using an adapted version of the Childhood Experience of Care and Abuse (CECA.Q) and the Retrospective Bullying Questionnaire (RBQ) and underwent magnetic resonance imaging (MRI) scans. Correlation analyses were used to assess associations between brain maps of CA and FEP effects. General linear models (GLMs) were performed to assess the interaction effects of CA and FEP on CT.ResultsEighty-three individuals with FEP and 83 HCs reported exposure to at least one CA. CT alterations in FEP were similar to those found in participants exposed to separation from parents, bullying, parental discord, household poverty, and sexual abuse (r = 0.50 to 0.25). Exposure to neglect (β = −0.24, 95% CI [−0.37 to −0.12], p = 0.016) and overall maltreatment (β = −0.13, 95% CI [−0.20 to −0.06], p = 0.043) were associated with cortical thinning in the right medial orbitofrontal region.ConclusionsCortical alterations in individuals with FEP are similar to those observed in the context of socio-environmental adversity. Neglect and maltreatment may contribute to CT reductions in FEP. Our findings provide new insights into the specific neurobiological effects of CA in early psychosis.
PB Cambridge University Press
SN 0033-2917
YR 2024
FD 2024-12-16
LK https://hdl.handle.net/20.500.14352/134227
UL https://hdl.handle.net/20.500.14352/134227
LA eng
NO Fares-Otero NE, Verdolini N, Melero H, Andrés-Camazón P, Vilajosana E, Cavone V, García-Bueno B, Rapado-Castro M, Izquierdo A, Martín-Hernández D, Mola Cárdenes P, Leal I, Dompablo M, Ortiz-Tallo A, Martinez-Gras I, Muñoz-Sanjose A, Loeck de Lapuerta C, Rodriguez-Jimenez R, Díaz Marsá M, Bravo-Ortiz MF, Ibañez A, Baca-García E, Vieta E, Ayuso-Mateos JL, Malpica N, Arango C, Díaz-Caneja CM, Radua J. Triangulating the associations of different types of childhood adversity and first-episode psychosis with cortical thickness across brain regions. Psychol Med. 2024 Dec 16:1-14. doi: 10.1017/S0033291724002393
NO Comunidad Autómona de Madrid
DS Docta Complutense
RD 7 abr 2026