RT Book, Section
T1 New insights in ghrelin orexigenic effect
A1 Diéguez, Carlos
A1 Da Boit, Kátia
A1 Garrido Novelle, Marta
A1 Martínez de Morentin, Pablo
A1 Nogueiras, Rubén
A1 López, Miguel
AB Ghrelin, a peptide hormone first discovered as the endogenous ligand of the growth hormone secretagogue receptor (GHS-R), is predominantly produced and released into the circulation by ghrelin cells (X/A-like) of the stomach fundus cells. Ghrelin has multiple actions in multiple tissues. In particular, it is the most potent known endogenous orexigenic peptide, and plays a significant role in glucose homeostasis: deletion of the genes encoding ghrelin and/or its receptor prevents high-fat diet from inducing obesity, increases insulin levels, enhances glucose-stimulated insulin secretion and improves peripheral insulin sensitivity. In addition to its already mentioned roles, ghrelin has other activities including stimulation of pituitary hormones secretion, regulation of gastric and pancreatic activity, modulation of fatty acid metabolism via specific control of AMP-activated protein kinase (AMPK), and cardiovascular and hemodynamic activities. In addition, modulation of cartilage and bone homeostasis, sleep and behavioral influences, and modulation of the immune system, as well as effects on cell proliferation, are other relevant actions of ghrelin. In this review, we summarize several aspects of ghrelin effects at hypothalamic level and their implications in the control of food intake and energy balance.
PB Karger
SN 978-3-8055-9444-8
SN 978-3-8055-9445-5
YR 2010
FD 2010
LK https://hdl.handle.net/20.500.14352/94364
UL https://hdl.handle.net/20.500.14352/94364
LA eng
NO Carlos Diéguez, Kátia Da Boit, Marta G. Novelle, Pablo B. Martínez de Morentin, Rubén Nogueiras, Miguel López, 2010. "New Insights in Ghrelin Orexigenic Effect", Pituitary Today II: New Molecular, Physiological and Clinical Aspects, E. Arzt, M. Bronstein, M. Guitelman
NO This work was supported by the European Community (Health-F2–2008–223713, ‘REPROBESITY’), and by Xunta de Galicia (ML: GRC2006/66), Fondo Investigationes Sanitarias (ML: PI061700), Ministerio de Educacion y Ciencia (ML: RyC-2007–00211 and RN: RYC-2008–02219), BFU 2008 (C.D. and M.L.). CIBER de Fisiopatología de la Obesidad y Nutrición is an initiative of ISCIII, Spain.
NO European Commission
NO Xunta de Galicia
NO Ministerio de Educación y Ciencia (España)
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 9 abr 2025