RT Journal Article
T1 A mucosal vaccine prevents eosinophilic allergic airway inflammation by modulating immune responses to allergens in a murine model of airway disease
A1 Angelina Querencias, Alba
A1 Lavín Plaza, Begoña
A1 Martín De La Cruz, Leticia
A1 Palomares Gracia, Óscar
A1 Pérez Diego, Mario
A1 Conejero, Laura
A1 Gayá, Auba
A1 Maldonado, Ángel
A1 Marcos-Ramiro, Beatriz
A1 Pérez de Llano, Luis
A1 Real, Francisco Xavier
A1 Sevilla Ortega, Carmen
A1 Subiza, José Luis
AB Allergic sensitization and viral infections are risk factors for asthma development and progression. Sublingual vaccination with MV130, a whole heat-inactivated polybacterial preparation, protects against viral infections, but its impact on allergic sensitization and asthma development remains unknown. Here we show MV130 prevents house dust mite (HDM)-induced local type 2 immune responses and associated eosinophilic airway inflammation, conferring protection up to 9 weeks after vaccination. MV130 reduces pathophysiological and clinical asthma features in an in vivo experimental mouse model of HDM-induced allergic eosinophilic asthma, restoring normal airway functionality. MV130 impairs allergen-specific IgE sensitization and systemic type 2 inflammation endorsing type 1 and IL-10 responses. In human DCs, MV130 induces a transcriptomic and metabolic reprogramming, and restores non-pathological immune responses to allergens in healthy and asthmatic donors. Additionally, the adoptive transfer of MV130-stimulated BMDCs was sufficient to reproduce the protective features of the vaccine administration in vivo. Collectively, we show MV130 reduces allergic sensitization and eosinophilic asthma. Our findings support the exploration of mucosal interventions aimed at reducing the risk of allergen-induced asthma development.
PB Springer Nature
YR 2025
FD 2025-08-03
LK https://hdl.handle.net/20.500.14352/132959
UL https://hdl.handle.net/20.500.14352/132959
LA eng
NO Sevilla-Ortega C, Angelina A, Martín-Cruz L, Pérez-Diego M, Maldonado A, Lavín B, Marcos-Ramiro B, Pérez de Llano L, Gayá A, Real FX, Conejero L, Subiza JL, Palomares O. A mucosal vaccine prevents eosinophilic allergic airway inflammation by modulating immune responses to allergens in a murine model of airway disease. Nat Commun. 2025 Aug 3;16(1):7129. doi: 10.1038/s41467-025-62632-x
NO Universidad Complutense de Madrid
NO Comunidad de Madrid
NO Inmunotek SL
NO Ministerio de Ciencia, Innovación y Universidades
NO Centro de Excelencia Severo Ochoa
DS Docta Complutense
RD 28 abr 2026