RT Journal Article
T1 Neuroprotective properties of queen bee acid by autophagy induction
A1 Martínez Chacón, Guadalupe
A1 Morales García, José Ángel
A1 Bravo San Pedro, José Manuel
A1 Niso Santano, Mireia
AB Autophagy is a conserved intracellular catabolic pathway that removes cytoplasmic components to contribute to neuronal homeostasis. Accumulating evidence has increasingly shown that the induction of autophagy improves neuronal health and extends longevity in several animal models. Therefore, there is a great interest in the identification of effective autophagy enhancers with potential nutraceutical or pharmaceutical properties to ameliorate age-related diseases, such as neurodegenerative disorders, and/or promote longevity. Queen bee acid (QBA, 10-hydroxy-2-decenoic acid) is the major fatty acid component of, and is found exclusively in, royal jelly, which has beneficial properties for human health. It is reported that QBA has antitumor, anti-inflammatory, and antibacterial activities and promotes neurogenesis and neuronal health; however, the mechanism by which QBA exerts these effects has not been fully elucidated. The present study investigated the role of the autophagic process in the protective effect of QBA. We found that QBA is a novel autophagy inducer that triggers autophagy in various neuronal cell lines and mouse and fly models. The beclin-1 (BECN1) and mTOR pathways participate in the regulation of QBA-induced autophagy. Moreover, our results showed that QBA stimulates sirtuin 1 (SIRT1), which promotes autophagy by the deacetylation of critical ATG proteins. Finally, QBA-mediated autophagy promotes neuroprotection in Parkinson’s disease in vitro and in a mouse model and extends the lifespan of Drosophila melanogaster. This study provides detailed evidences showing that autophagy induction plays a critical role in the beneficial health effects of QBA.
PB Springer Nature
SN 0742-2091
SN 1573-6822
YR 2021
FD 2021-08-27
LK https://hdl.handle.net/20.500.14352/111060
UL https://hdl.handle.net/20.500.14352/111060
LA eng
NO Martínez-Chacón, G., Paredes-Barquero, M., Yakhine-Diop, S.M. et al. Neuroprotective properties of queen bee acid by autophagy induction. Cell Biol Toxicol 39, 751–770 (2023). https://doi.org/10.1007/s10565-021-09625-w
NO Junta de Extremadura
NO Ministerio de Ciencia e Innovación (España)
NO Unión Europea
NO Generalitat Valenciana
DS Docta Complutense
RD 9 abr 2025