RT Journal Article
T1 Functional Response of Hepatocytes Transplanted into Gunn Rats Stimulated with Thyroid Hormone
A1 Cubero Palero, Francisco Javier
A1 Manganto, Paloma
A1 Mula, Nieves
A1 Ortiz, Agustín
A1 Barrutia, María G.
A1 Codesal, Francisco J.
A1 Arahuetes, Rosa M.
AB In the attempt to translate laboratory studies into clinical practice, the small number of cells that can be transplanted is currently a problem to be solved. The aim of this work is to study the functional response of intrasplenically transplanted syngeneic rat adult and fetal hepatocytes to a proliferative stimulus, 3,5,3'-triiodothyronine. Total serum bilirubin significantly decreased from 7 to 90 days after fetal hepatocyte transplantation and from 24 hr to 30 days after adult hepatocyte transplantation. Concomitant with these changes, bile conjugated bilirubin increased from 7 to 90 days after fetal and from 24 hr to 30 days after adult hepatocyte transplantation. In both cases, administration of thyroid hormone enhances this effect. We conclude that although adult and fetal hepatocytes correct the hyperbilirubinemia, fetal cells function longer than adult hepatocytes. Thyroid hormone is a powerful stimulator of function of hepatocytes since it improves both adult and fetal response.
PB Springer
SN 1573-2568
YR 2006
FD 2006-12-12
LK https://hdl.handle.net/20.500.14352/97097
UL https://hdl.handle.net/20.500.14352/97097
LA eng
NO Cubero FJ, Maganto P, Mula N, Ortiz A, Barrutia MG, Codesal FJ, Arahuetes RM. Functional response of hepatocytes transplanted into Gunn rats stimulated with thyroid hormone. Dig Dis Sci. 2007 Jan;52(1):210-6. doi: 10.1007/s10620-006-9614-2. Epub 2006 Dec 12. PMID: 17160715.
NO Spanish Social Security Funds for Research
DS Docta Complutense
RD 4 abr 2025