RT Journal Article T1 Differences in Dry Eye Questionnaire Symptoms in Two Different Modalities of Contact Lens Wear: Silicone-Hydrogel in Daily Wear Basis and Overnight Orthokeratology A1 García Porta, Nery A1 Rico Del Viejo, Laura A1 Martín Gil, Alba A1 Pintor Just, Jesús Jerónimo A1 Carracedo Rodríguez, Juan Gonzalo A1 González Méijome, José Manuel AB Purpose. To compare the ocular surface symptoms and signs in an adult population of silicone-hydrogel (Si-Hy) contact lens (CL) wearers with another modality of CL wear, overnight orthokeratology (OK). Materials and Methods. This was a prospective and comparative study in which 31 myopic subjects were fitted with the same Si-Hy CL and 23 underwent OK treatment for 3 months. Dry eye questionnaire (DEQ) was filled in at the beginning of the study and then after 15 days, 1 month, and 3 months using each CL modality. The tear quality was evaluated with noninvasive tear break-up time. Tear production was measured with Schirmer test. Tear samples were collected with Schirmer strips being frozen to analyze the dinucleotide diadenosine tetraphosphate (Ap4A) concentration with High-Performance Liquid Chromatography (HPLC). Results. After refitting with ortho-k, a reduction in discomfort and dryness symptoms at the end of the day (, ) was observed. No significant changes were observed in Ap4A concentration in any group. Bulbar redness, limbal redness, and conjunctival staining increased significantly in the Si-Hy group (, Kruskal–Wallis test). Conclusion. Discomfort and dryness symptoms at the end of the day are lower in the OK CL group than in the Si-Hy CL group. PB Hindawi Publishing Corporation SN 2314-6133 YR 2016 FD 2016-08 LK https://hdl.handle.net/20.500.14352/17686 UL https://hdl.handle.net/20.500.14352/17686 LA eng NO García Porta, N., Rico Del Viejo, L., Martín Gil, A. et al. «Differences in Dry Eye Questionnaire Symptoms in Two Different Modalities of Contact Lens Wear: Silicone-Hydrogel in Daily Wear Basis and Overnight Orthokeratology». BioMed Research International, vol. 2016, 2016, pp. 1-9. DOI.org (Crossref), https://doi.org/10.1155/2016/1242845. NO Xunta de Galicia NO Redes Temáticas de Investigación Cooperativa en Salud (España) NO Fundación para la Ciencia y la Tecnología (Portugal) DS Docta Complutense RD 10 abr 2025