RT Conference Proceedings
T1 Pharmacokinetics of marbofloxacin, after one bolus oral administration in buffaloes calves: Preliminary study
A1 Baroni, Eduardo
A1 Rubio Langre, Sonia
A1 Diaz, D.
A1 Crudeli, G.
A1 Lucas Burneo, José Julio De
A1 Rodríguez Fernández, Casilda
A1 San Andrés Larrea, Manuel Ignacio
AB Buffalo breeding system has a great economic importance in South-America, principally in marginal or sub-tropical lands. The therapeutic recommendations applied to a single ruminant species are extrapolated to others but important differences among those were recognized. Marbofloxacin bolus is indicated in the treatment of neonatal gastroenteritis caused by Escherichia coli, in calves (25-50kg). The aim of this study was determined the pharmacokinetic behaviour of marbofloxacin after oral administration, as bolus, following the label approved recommendations to cattle. One bolus (50 mg) was administered in two clinically healthy buffaloes (two days-old, 48-50kg). Plasma concentrations of the marbofloxacin were determined by a HPLC/u.v. method. After oral administration, the values obtained were: tmax=0.5-6h, Cmax= 1.19-0.04μg/mL, AUCt=1.57-0.38μg·h/mL and MRTt= 3.34-6.92h, for calves 1 and 2 respectively. Fluoroquinolones act by concentration dependant killing mechanism, so high plasma concentration initially is important. For this reason, the recommended dose of 1mg/kg is inadequate in buffaloes.
SN 1594-4077
YR 2007
FD 2007
LK https://hdl.handle.net/20.500.14352/112353
UL https://hdl.handle.net/20.500.14352/112353
LA eng
NO Baroni, E. E., Rubio, S., Diaz, D. C., Crudeli, G., de Lucas, J. J., Rodríguez, C., & San Andrés, M. I. (2007). Pharmacokinetics of marbofloxacin, after one bolus oral administration in buffaloes calves: Preliminary study. Italian Journal of Animal Science, 6(sup2), 835–837. https://doi.org/10.4081/ijas.2007.s2.835
DS Docta Complutense
RD 4 abr 2025