RT Journal Article
T1 Beractant and poractant alfa in premature neonates with respiratory distress syndrome: a systematic review of real-world evidence studies and randomized controlled trials
A1 Sánchez Luna, Manuel
A1 Sánchez Luna, Manuel Ramón
A1 Bacher, Peter
A1 Unnebrink, Kristina
A1 Martinez Tristani, Marisol
A1 Ramos Navarro, Cristina
AB Findings from previous meta-analyses of randomized clinical trials (RCTs) in premature infants with respiratory distress syndrome (RDS) varied as to whether clinical outcomes differed by type of animal-derived pulmonary surfactant; real-world evidence (RWE) was excluded. We extracted study characteristics and outcomes from full-text articles from a systematic search for studies that compared beractant with poractant alfa for RDS in preterm infants. RWE data were tabulated; RCT data were subjected to meta-analyses. Designs, patient characteristics, and follow-up durations varied widely among studies (4 RWE, 15 RCT). RWE studies with adjusted odds ratios (ORs) found no statistically significant between-treatment differences in outcomes. In RCT meta-analyses, no statistically significant between-treatment differences were observed for death (OR [95% confidence interval], 1.35 [0.98-1.86]), bronchopulmonary dysplasia (1.25 [0.96-1.62]), pneumothorax (1.21 [0.72-2.05]), and air leak syndrome (2.28 [0.82-6.39]). Collectively, outcomes were similar with beractant and poractant alfa in RWE studies and pooled RCTs.
PB Springer Nature
SN 0743-8346
SN 1476-5543
YR 2020
FD 2020-02-12
LK https://hdl.handle.net/20.500.14352/99359
UL https://hdl.handle.net/20.500.14352/99359
LA eng
NO Sánchez Luna M, Bacher P, Unnebrink K, Martinez-Tristani M, Ramos Navarro C. Beractant and poractant alfa in premature neonates with respiratory distress syndrome: a systematic review of real-world evidence studies and randomized controlled trials. J Perinatol. 2020 Aug;40(8):1121-1134. doi: 10.1038/s41372-020-0603-7. Epub 2020 Feb 12. PMID: 32051542; PMCID: PMC7375954.
NO AbbVie
DS Docta Complutense
RD 24 ago 2024