RT Journal Article
T1 Differential effects of environmental enrichment and isolation housing on the hormonal and neurochemical responses to stress in the prefrontal cortex of the adult rat: relationship to working and emotional memories.
A1 Garrido, Pedro
A1 Blas, Marta De
A1 Ronzoni Blázquez, Giacomo
A1 Cordero Álvarez, Clara Isabel
A1 Antón Hurtado, Olga María
A1 Giné Domínguez, Elena
A1 Santos Montes, Gregorio Ángel
A1 Arco González, Alberto Del
A1 Segovia Camargo, Gregorio
A1 Mora Teruel, Francisco
AB The present study was designed to investigate the modulation of the stress responses by the environmental conditions and its putative neurobiological mechanisms. For that an integrative study on the effects of environmental enrichment and isolation housing on (1) the corticosterone, dopamine and acetylcholine responses to acute restraint stress in the prefrontal cortex (PFC) of the awake rat; (2) the mRNA levels of glucocorticoid receptors (GRs) in the PFC, and (3) the behavioral responses to stress, related to the PFC (habituation to a novel environment, spatial-working memory and inhibitory avoidance response) was performed. Male Wistar rats were maintained from 3 to 6 months of age in two different conditions: enriched (EC) or impoverished (IC). Animals were stereotaxically implanted with bilateral guide cannulae in the PFC to perform microdialysis experiments to evaluate the concentrations of corticosterone, dopamine and acetylcholine. EC animals showed lower increases of corticosterone and dopamine but not of acetylcholine than IC animals in the PFC in response to acute restraint stress (20 min). In the PFC, GR mRNA levels showed a trend towards an enhancement in EC animals. EC reduced the days to learn the spatial working memory task (radial-water maze). Spatial working memory, however, was not different between groups in either basal or stress conditions. Inhibitory avoidance response was reduced in EC rats. The changes produced by EC in the neurochemical, neuroendocrine and behavioral parameters evaluated suggest that EC rats could show a better coping during an acute stress challenge.
PB Springer Verlag
SN 1435-1463
YR 2013
FD 2013
LK https://hdl.handle.net/20.500.14352/33648
UL https://hdl.handle.net/20.500.14352/33648
LA eng
NO Garrido, P., Blas, M., Ronzoni Blázquez, G. et al. «Differential Effects of Environmental Enrichment and Isolation Housing on the Hormonal and Neurochemical Responses to Stress in the Prefrontal Cortex of the Adult Rat: Relationship to Working and Emotional Memories». Journal of Neural Transmission, vol. 120, n.o 5, mayo de 2013, pp. 829-43. DOI.org (Crossref), https://doi.org/10.1007/s00702-012-0935-3.
DS Docta Complutense
RD 3 jul 2025