%0 Journal Article
%A Cabezas Quintario, María Antonia
%A Gomez Iglesias, Patricia
%A Yuste Del Pozo, Verónica
%A Valencia Mesa, Ana
%A Sosa, Grevelyn
%A Ricard, Patricia
%A Hijas Gómez, Ana
%A Pinedo, Fernando
%A Arguelles, Miguel
%T Bone marrow trephine biopsy involvement by lymphoma: pattern of involvement and concordance with flow cytometry, in 10 years from a single institution
%D 2015
%@ 1699-048X
%U https://hdl.handle.net/20.500.14352/116469
%X Purpose: To evaluate the features of bone marrow (BM) biopsy involvement by lymphoma, pattern of infiltration, morphological analysis and flow cytometry were reviewed at all lymphoma patients over a period of 10 years.Methods/patients: 413 cases were included in the study if BM biopsy slides were available. Only 356 patients had both BM trephine biopsy and flow cytometry.Results: The most frequent subtype was diffuse large B cell (31.2%), followed by follicular lymphoma (18.9%). The predominant pattern was mixed (nodular-interstitial) (9.2%). Morphological marrow infiltration was found in 138 cases, and flow cytometry identified 117 cases with BM involvement. A concordance between the two methods was detected in 305 cases (85.7%). There was discordance in 51 cases (14.3%): morphology positive/FC negative in 33 cases and morphology negative/FC positive in 18.Conclusions: Flow cytometry is slightly more useful in detecting involvement when the BM is affected, but this finding is not conclusive.
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