RT Journal Article
T1 Bone marrow trephine biopsy involvement by lymphoma: pattern of involvement and concordance with flow cytometry, in 10 years from a single institution
A1 Cabezas Quintario, María Antonia
A1 Gomez Iglesias, Patricia
A1 Yuste Del Pozo, Verónica
A1 Valencia Mesa, Ana
A1 Sosa, Grevelyn
A1 Ricard, Patricia
A1 Hijas Gómez, Ana
A1 Pinedo, Fernando
A1 Arguelles, Miguel
AB Purpose: To evaluate the features of bone marrow (BM) biopsy involvement by lymphoma, pattern of infiltration, morphological analysis and flow cytometry were reviewed at all lymphoma patients over a period of 10 years.Methods/patients: 413 cases were included in the study if BM biopsy slides were available. Only 356 patients had both BM trephine biopsy and flow cytometry.Results: The most frequent subtype was diffuse large B cell (31.2%), followed by follicular lymphoma (18.9%). The predominant pattern was mixed (nodular-interstitial) (9.2%). Morphological marrow infiltration was found in 138 cases, and flow cytometry identified 117 cases with BM involvement. A concordance between the two methods was detected in 305 cases (85.7%). There was discordance in 51 cases (14.3%): morphology positive/FC negative in 33 cases and morphology negative/FC positive in 18.Conclusions: Flow cytometry is slightly more useful in detecting involvement when the BM is affected, but this finding is not conclusive.
PB Springer
SN 1699-048X
YR 2015
FD 2015-08-27
LK https://hdl.handle.net/20.500.14352/116469
UL https://hdl.handle.net/20.500.14352/116469
LA eng
NO Cabezas-Quintario MA, Gomez P, Yuste-Del Pozo V, Valencia-Mesa AL, Sosa G, Ricard P, et al. Bone marrow trephine biopsy involvement by lymphoma: pattern of involvement and concordance with flow cytometry, in 10 years from a single institution. Clinical and Translational Oncology [Internet]. 2015 Aug 27;18(5):537–40. Available from: http://dx.doi.org/10.1007/s12094-015-1393-9
DS Docta Complutense
RD 7 abr 2025