RT Journal Article
T1 Clinicopathologic correlations of renal microthrombosis and inflammatory markers in proliferative lupus nephritis
A1 Gonzalo, Elena
A1 Toldos González, Óscar
A1 Pablos Álvarez, José Luis
A1 Galindo Izquierdo, María
AB IntroductionMicrothrombosis is often observed in lupus nephritis (LN) lesions, but its clinical significance is unknown. We evaluated the clinicopathologic correlations of renal microthrombosis and inflammatory markers in LN.                       MethodsKidney biopsies from 58 patients with systemic lupus erythematosus (SLE) proliferative nephritis were analyzed with immunohistochemistry (IHC) for intravascular platelet aggregates (CD61), macrophagic infiltration (CD68), and activated complement deposition (C4d). Clinical data at the time of kidney biopsy and follow-up were analyzed with regard to pathologic IHC data.                      ResultsMicrothrombosis was present in 52% of the tissues. It was significantly more prevalent in patients with antiphospholipid antibodies (aPLs) (62% versus 42%). The presence of microthrombosis significantly correlated with higher macrophagic infiltration. Macrophagic infiltration but not microthrombosis was significantly correlated with C4d deposition. Only macrophagic infiltration showed a correlation with SLE and renal activity (proteinuria and active sediment), whereas neither the presence of CD61+ microthrombi nor the extent of C4d deposition correlated with LN severity or outcome.                     Conclusions                      Microthrombosis is associated with higher macrophagic infiltration in LN but does not seem to increase independently the severity of renal damage. Macrophagic infiltration was the best marker of SLE and renal activity in this LN series.
PB BMC Springer Nature
SN 1478-6354
YR 2012
FD 2012
LK https://hdl.handle.net/20.500.14352/114098
UL https://hdl.handle.net/20.500.14352/114098
LA eng
NO Gonzalo E, Toldos O, Martínez-Vidal MP, Ordoñez MC, Santiago B, Fernández-Nebro A, Loza E, García I, León M, Pablos JL, Galindo M. Clinicopathologic correlations of renal microthrombosis and inflammatory markers in proliferative lupus nephritis. Arthritis Res Ther. 2012 May 28;14(3):R126.
NO Fondo de Investigación Sanitaria (PI06/90374)
NO RIER (Red de Inflamación y Enfermedades Reumáticas RD08/0075)
DS Docta Complutense
RD 17 abr 2025