%0 Journal Article
%A Muñoz Úbeda, Mónica
%A Carniato, Fabio
%A Catanzaro, Valeria
%A Padovan, Sergio
%A Grange, Cristina
%A Porta, Stefano 
%A Carrera, Carla
%A Tei, Lorenzo
%A Digilio, Giuseppe
%T Gadolinium-decorated silica microspheres as redox-responsive MRI probes for applications in cell therapy follow-up
%D 2016
%@ 0947-6539
%U https://hdl.handle.net/20.500.14352/91192
%X The redox microenvironment within a cell graft can be considered as an indicator to assess whether the graft is metabolically active or hypoxic. We present a redox-responsive MRI probe based on porous silica microparticles whose surface has been decorated with a Gdchelate through a disulphide bridge. Such microparticles are designed to be interspersed with therapeutic cells within a biocompatible hydrogel. The onset of reducing conditions within the hydrogel is paralleled by an increased clearance of Gd, that can be detected by MRI.
%~