RT Journal Article
T1 Gadolinium-decorated silica microspheres as redox-responsive MRI probes for applications in cell therapy follow-up
A1 Muñoz Úbeda, Mónica
A1 Carniato, Fabio
A1 Catanzaro, Valeria
A1 Padovan, Sergio
A1 Grange, Cristina
A1 Porta, Stefano
A1 Carrera, Carla
A1 Tei, Lorenzo
A1 Digilio, Giuseppe
AB The redox microenvironment within a cell graft can be considered as an indicator to assess whether the graft is metabolically active or hypoxic. We present a redox-responsive MRI probe based on porous silica microparticles whose surface has been decorated with a Gdchelate through a disulphide bridge. Such microparticles are designed to be interspersed with therapeutic cells within a biocompatible hydrogel. The onset of reducing conditions within the hydrogel is paralleled by an increased clearance of Gd, that can be detected by MRI.
PB Wiley
SN 0947-6539
YR 2016
FD 2016
LK https://hdl.handle.net/20.500.14352/91192
UL https://hdl.handle.net/20.500.14352/91192
LA eng
NO M. Muñoz Úbeda, F. Carniato, V. Catanzaro, S. Padovan, C. Grange, S. Porta, C. Carrera, L. Tei, G. Digilio, Chem. Eur. J. 2016, 22, 7716.
NO Ministry of Foreign Affairs and Cooperation (Italy)
NO Ministry of Education (Italy)
DS Docta Complutense
RD 17 abr 2025