RT Journal Article
T1 An NMR-Based Model to Investigate the Metabolic Phenoreversion of COVID-19 Patients throughout a Longitudinal Study
A1 Gil Redondo, Rubén
A1 Ramos Acosta, Carlos
A1 Anguita Mandly, Eduardo Luis
A1 Millet, Oscar
AB After SARS-CoV-2 infection, the molecular phenoreversion of the immunological response and its associated metabolic dysregulation are required for a full recovery of the patient. This process is patient-dependent due to the manifold possibilities induced by virus severity, its phylogenic evolution and the vaccination status of the population. We have here investigated the natural history of COVID-19 disease at the molecular level, characterizing the metabolic and immunological phenoreversion over time in large cohorts of hospitalized severe patients (n = 886) and non-hospitalized recovered patients that self-reported having passed the disease (n = 513). Non-hospitalized recovered patients do not show any metabolic fingerprint associated with the disease or immune alterations. Acute patients are characterized by the metabolic and lipidomic dysregulation that accompanies the exacerbated immunological response, resulting in a slow recovery time with a maximum probability of around 62 days. As a manifestation of the heterogeneity in the metabolic phenoreversion, age and severity become factors that modulate their normalization time which, in turn, correlates with changes in the atherogenesis-associated chemokine MCP-1. Our results are consistent with a model where the slow metabolic normalization in acute patients results in enhanced atherosclerotic risk, in line with the recent observation of an elevated number of cardiovascular episodes found in post-COVID-19 cohorts.
PB MDPI
SN 2218-1989
YR 2022
FD 2022-12-01
LK https://hdl.handle.net/20.500.14352/105420
UL https://hdl.handle.net/20.500.14352/105420
LA eng
NO Gil-Redondo, Rubén, Ricardo Conde, Maider Bizkarguenaga, Chiara Bruzzone, Ana Laín, Beatriz González-Valle, Milagros Iriberri, Carlos Ramos-Acosta, Eduardo Anguita, Juan Ignacio Arriaga Lariz, and et al. 2022. "An NMR-Based Model to Investigate the Metabolic Phenoreversion of COVID-19 Patients throughout a Longitudinal Study" Metabolites 12, no. 12: 1206. https://doi.org/10.3390/metabo12121206
NO Gobierno Vasco
NO BIOEF EITB Maratoia
NO European Research Council
NO The Spinnaker Health Research Foundation
NO The McCusker Foundation
NO The Western Australian State Government
DS Docta Complutense
RD 20 ago 2024