RT Journal Article
T1 3D printed spherical mini-tablets: Geometry versus composition effects in controlling dissolution from personalised solid dosage forms
A1 Ayyoubi, Sejad
A1 Cerda, Jose R.
A1 Fernández García, Raquel
A1 Knief, Peter
A1 Lalatsa, Aikaterini
A1 Healy, Anne Marie
A1 Serrano López, Dolores Remedios
AB Oral dosage forms are by far the most common prescription and over-the-counter pharmaceutical dosage forms used worldwide. However, many patients suffer from adverse effects caused by their use of “one-size fits all” mass produced commercially available solid dosage forms, whereby they do not receive dedicated medication or dosage adjusted to their specific needs. The development of 3D printing paves the way for personalised medicine. This work focuses on personalised therapies for hypertensive patients using nifedipine as the model drug. 3D printed full solid and channelled spherical mini-tablets with enhanced surface area (1.6-fold higher) were printed using modified PVA commercial filaments loaded by passive diffusion (PD), and Kollidon VA64 (KVA) and ethylcellulose (EC) based filaments prepared by hot-melt extrusion (HME). Drug loading ranged from 3.7% to 60% based on the employed technique, with a 13-fold higher drug loading achieved with the HME compared to PD. Composition was found to have a more significant impact on drug dissolution than geometry and surface area. Both KVA and EC-based formulations exhibited a biphasic zero-order drug-release profile. Physicochemical characterization revealed that nifedipine was in the amorphous form in the KVA-based end-products which led to a greater dissolution control over a 24 h period compared to the EC-based formulations that exhibited low levels of crystallinity by PXRD. The proposed 3D printed spherical mini-tablets provide a versatile technology for personalised solid dosage forms with high drug loading and dissolution control, easily adaptable to patient and disease needs.
PB Elsevier
YR 2021
FD 2021
LK https://hdl.handle.net/20.500.14352/132305
UL https://hdl.handle.net/20.500.14352/132305
LA eng
NO Ayyoubi S, Cerda JR, Fernández-García R, et al. 3D printed spherical mini-tablets: Geometry versus composition effects in controlling dissolution from personalised solid dosage forms. International Journal of Pharmaceutics 2021;597:120336. https://doi.org/10.1016/j.ijpharm.2021.120336
NO European Commission
NO Universidad Complutense de Madrid
NO European Regional Development Fund
DS Docta Complutense
RD 17 mar 2026