RT Journal Article
T1 Utility of Transient Elastography for the Screening of Liver Disease in Patients with Alpha1-Antitrypsin Deficiency
A1 Pons, Mònica
A1 Núñez, Alexa
A1 Esquinas, Cristina
A1 Torres Durán, María
A1 Rodríguez Hermosa, Juan Luis
A1 Calle Rubio, Myrian
A1 Tubio Pérez, Ramón
A1 Belmonte, Irene
A1 Rodríguez Frías, Francisco
A1 Rodríguez, Esther
A1 Genescà, Joan
A1 Miravitlles, Marc
A1 Barrecheguren, Miriam
AB Screening of liver disease in alpha-1 antitrypsin deficiency (AATD) is usually carried out with liver enzymes, with low sensitivity. We conducted a multicenter cross-sectional study aiming to describe the utility of transient elastography for the identification of liver disease in patients with AATD. A total of 148 AATD patients were included. Among these, 54.7% were Pi*ZZ and 45.3% were heterozygous for the Z allele. Between 4.9% and 16.5% of patients had abnormal liver enzymes, without differences among genotypes. Liver stiffness measurement (LSM) was significantly higher in Pi*ZZ individuals than in heterozygous Z (5.6 vs. 4.6 kPa; p = 0.001). In total, in 8 (5%) individuals LSM was >7.5 kPa, considered significant liver fibrosis, and ≥10 kPa in 3 (1.9%) all being Pi*ZZ. Elevated liver enzymes were more frequently observed in patients with LSM > 7.5 kPa, but in 5 out of 8 of these patients all liver enzymes were within normal range. In patients with AATD, the presence of abnormal liver enzymes is frequent; however, most of these patients do not present significant liver fibrosis. Transient elastography can help to identify patients with liver fibrosis even with normal liver enzymes and should be performed in all Z-allele carriers to screen for liver disease.
PB MPDI
SN 2077-0383
YR 2021
FD 2021-04-16
LK https://hdl.handle.net/20.500.14352/6965
UL https://hdl.handle.net/20.500.14352/6965
LA eng
NO Pons M, Núñez A, Esquinas C, Torres-Durán M, Rodríguez-Hermosa J, Calle M, et al. Utility of Transient Elastography for the Screening of Liver Disease in Patients with Alpha1-Antitrypsin Deficiency. JCM 2021;10:1724. https://doi.org/10.3390/jcm10081724.
NO Grifols
DS Docta Complutense
RD 23 abr 2025