RT Journal Article
T1 Maxillary growth in a congenital cleft palate canine model for surgical research
A1 Paradas Lara, Irene
A1 Casado Gómez, Inmaculada
A1 Martín, Conchita
A1 Martínez Sanz, Elena
A1 López Gordillo, Yamila
A1 González, Pablo
A1 Rodríguez Bobada, Cruz
A1 Chamorro, Manuel
A1 Arias, Pablo
A1 Maldonado Bautista, Estela
A1 Ortega Aranegui, Ricardo
A1 Berenguer, Beatriz
A1 Martínez Álvarez, María Concepción
AB We have recently presented the Old Spanish Pointer dog, with a 15-20% spontaneous congenital cleft palate rate, as a unique experimental model of this disease. This study aimed to describe the cleft palate of these dogs for surgical research purposes and to determine whether congenital cleft palate influences maxillofacial growth. Seven newborn Old Spanish Pointer dogs of both sexes, comprising a cleft palate group (n = 4) and a normal palate group (n = 3), were fed using the same technique. Macroscopic photographs and plaster casts from the palate, lateral radiographs and computer tomograms of the skull were taken sequentially over 41 weeks, starting at week 5. The cleft morphology, the size and the tissue characteristics in these dogs resembled the human cleft better than current available animal models. During growth, the cleft width varies. Most of the transverse and longitudinal measures of the palate were statistically lower in the cleft palate group. The cleft palate group showed hypoplasia of the naso-maxillary complex. This model of congenital cleft palate seems suitable for surgical research purposes. A reduced maxillofacial pre- and post-natal development is associated to the congenital cleft palate in the Old Spanish Pointer dog.
PB Elsevier
SN 1010-5182
YR 2014
FD 2014
LK https://hdl.handle.net/20.500.14352/101455
UL https://hdl.handle.net/20.500.14352/101455
LA eng
NO Paradas-Lara, I., Casado-Gómez, I., Martín, C., Martínez-Sanz, E., López-Gordillo, Y., González, P., ... & Martínez-Álvarez, C. (2014). Maxillary growth in a congenital cleft palate canine model for surgical research. Journal of Cranio-Maxillofacial Surgery, 42(1), 13-21.
NO Ministerio de Sanidad de España
NO Osteology Foundation
NO Universidad Complutense de Madrid
NO Banco Santander
DS Docta Complutense
RD 28 sept 2024