RT Journal Article
T1 Canine spindle cell mammary tumor: a retrospective study of 67 cases
A1 Alonso Díez, Ángela
A1 Ramos, Antonio
A1 Roccabianca, Paola
A1 Barreno, Lucía
A1 Pérez Alenza, María de los Dolores
A1 Tecilla, Marcos
A1 Avallone, Giancarlo
A1 Gama, Adelina
A1 Fernández Peña, Laura
AB Canine spindle cell mammary tumor (CSCMT) is an infrequent canine mammary tumor (CMT) composed of spindle or fusiform cells, which represents a challenge for pathologists and clinicians. Mammary tumors submitted for histopathology from 1998 to 2013 and compatible with CSCMTs were retrospectively selected. The tumors were diagnosed based on the hematoxylin and eosin (HE)-stained section; malignant tumors were graded using a canine soft tissue sarcoma grading scheme and a canine mammary tumor grading scheme, and they were further assigned a diagnosis based on immunohistochemistry (IHC) for pancytokeratin, cytokeratin 14, p63, calponin, vimentin, Ki-67, CD31, desmin, myosin, smooth muscle actin, glial fibrillary acidic protein, and S-100. The origin of the tumors was assessed as mammary, skin, or unknown. The prevalence of CSCMT was 1% of all CMTs. CSCMTs included 3 benign tumors (1 angioma and 2 benign myoepitheliomas) and 67 malignant tumors that after IHC were diagnosed as malignant myoepithelioma (64%), carcinoma and malignant myoepithelioma (19%), hemangiosarcoma (8%), undifferentiated sarcoma (5%), peripheral nerve sheath tumor (3%), and fibrosarcoma (2%). The diagnosis based on the HE-stained section differed from the diagnosis after IHC in 75% of the malignant cases. The majority of malignant CSCMTs were solitary (57%) large tumors (6.42 ± 3.92 cm) with low metastatic potential and high survival rate (8% tumor-related mortality). Higher sarcoma grade was associated with older age (P = .034) and greater tumor size (P = .037). Malignant CSCMTs need to be evaluated by IHC to ensure the histotype and the relatively benign clinical behavior, despite their large size.
PB SAGE Publications
SN 0300-9858
YR 2019
FD 2019
LK https://hdl.handle.net/20.500.14352/140200
UL https://hdl.handle.net/20.500.14352/140200
LA eng
NO Alonso-Diez, Á., Ramos, A., Roccabianca, P., Barreno, L., Pérez-Alenza, M. D., Tecilla, M., Avallone, G., Gama, A., & Peña, L. (2019). Canine Spindle Cell Mammary Tumor: A Retrospective Study of 67 Cases. Veterinary pathology, 56(4), 526–535. https://doi.org/10.1177/0300985819829522
DS Docta Complutense
RD 13 nov 2026