RT Journal Article
T1 Efficacy of continuous glucose monitoring on maternal and neonatal outcomes in gestational diabetes mellitus: a systematic review and meta‐analysis of randomized clinical trials
A1 García‐Moreno, Rosa María
A1 Benítez‐Valderrama, Pamela
A1 Barquiel, Beatriz
A1 González Pérez‐de‐Villar, Noemí
A1 Hillman, Natalia
A1 Lora Pablos, David
A1 Herranz, Lucrecia
AB Aims.This systematic review aims to evaluate the effect of continuous glucose monitoring (CGM) on maternal and neonatal outcomes in gestational diabetes mellitus (GDM).Methods. Two authors conducted a systematic search using PubMed, Embase, CENTRAL, CINAHL, Scopus, Web of Science, ClinicalTrials.gov and the World Health Organization International Clinical Trials Registry Platform. The inclusion criteria for the systematic review were randomized clinical trials that compared the effects of CGM and blood glucose monitoring (BGM) in women with GDM. A restricted maximum likelihood random‐effects model was used for the meta‐analysis. The measures of effect were risk ratios for categorical data and mean differences for continuous data.Results. Of the 457 studies reviewed, six randomized clinical trials met the inclusion criteria. A total of 482 patients were included in the meta‐analysis. The use of CGM was associated with lower HbA1c levels at the end of pregnancy (mean difference: −0.22; 95%CI −0.42 to −0.03) compared to BGM. Women using CGM also had less gestational weight gain (mean difference: −1.17, 95%CI −2.15 to −0.19), and their children had lower birth weight (mean difference: −116.26, 95%CI −224.70 to −7.81). No differences were observed in the other outcomes evaluated.Conclusion. Women with GDM using CGM may achieve lower average blood glucose levels, lower maternal weight gain and infant birth weight than women using BGM. Nevertheless, current evidence is limited by the low number of studies and the small sample sizes of these studies. Larger clinical trials are needed to better understand the effects of CGM in GDM.Registration. PROSPERO registration ID CRD42021225651.
PB John Wiley & Sons Ltd
SN 0742-3071
YR 2022
FD 2022
LK https://hdl.handle.net/20.500.14352/116583
UL https://hdl.handle.net/20.500.14352/116583
LA eng
NO García-Moreno RM, Benítez-Valderrama P, Barquiel B, González Pérez-de-Villar N, Hillman N, Lora Pablos D, Herranz L. Efficacy of continuous glucose monitoring on maternal and neonatal outcomes in gestational diabetes mellitus: a systematic review and meta-analysis of randomized clinical trials. Diabet Med. 2022 Jan;39(1):e14703. doi: 10.1111/dme.14703. Epub 2021 Oct 13. PMID: 34564868.
DS Docta Complutense
RD 13 abr 2025