RT Journal Article
T1 Incidence of Candidemia Is Higher in COVID-19 versus Non-COVID-19 Patients, but Not Driven by Intrahospital Transmission
A1 Machado, Marina
A1 Estévez, Agustín
A1 Sánchez Carrillo, Carlos
A1 Guinea, Jesús
A1 Escribano, Pilar
A1 Alonso Fernández, Roberto
A1 Valerio, Maricela
A1 Padilla, Belén
A1 Bouza, Emilio
A1 Muñoz, Patricia
AB There is scarce information on the actual incidence of candidemia in COVID-19 patients. In addition, comparative studies of candidemia episodes in COVID-19 and non-COVID-19 patients are heterogeneous. Here, we assessed the real incidence, epidemiology, and etiology of candidemia in COVID-19 patients, and compared them with those without COVID-19 (2020 vs. 2019 and 2020, respectively). We also genotyped all C. albicans, C. parapsilosis, and C. tropicalis isolates (n = 88), causing candidemia in both groups, providing for the first time a genotypic characterization of isolates gathered in patients with either COVID-19 or non-COVID-19. Incidence of candidemia was higher in patients with COVID-19 than non-COVID-19 (4.73 vs. 0.85 per 1000 admissions; 3.22 vs. 1.14 per 10,000 days of stay). No substantial intergroup differences were found, including mortality. Genotyping proved the presence of a low number of patients involved in clusters, allowing us to rule out rampant patient-to-patient Candida transmission. The four patients, involved in two clusters, had catheter-related candidemia diagnosed in the first COVID-19 wave, which demonstrates breaches in catheter management policies occurring in such an overwhelming situation. In conclusion, the incidence of candidemia in patients with COVID-19 is significantly higher than in those without COVID-19. However, genotyping shows that this increase is not due to uncontrolled intrahospital transmission.
PB MPDI
SN 2309-608X
YR 2022
FD 2022-03-16
LK https://hdl.handle.net/20.500.14352/72506
UL https://hdl.handle.net/20.500.14352/72506
LA eng
NO Instituto de Salud Carlos III (ISCIII)/FEDER
NO Miguel Servet contract
DS Docta Complutense
RD 4 abr 2025